{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:47:19Z","timestamp":1791388039652,"version":"4.3.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The CARPE registry was set up in 2009 to prospectively investigate the management of patients with chronic hand eczema (CHE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report comprehensive follow\u2010up data from the CARPE registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We investigated sociodemographic and clinical characteristics, provision of medical care, physician\u2010assessed outcomes, and patient\u2010reported outcomes (PROs). Data were collected between 2009 and 2016, with up to 5 years of follow\u2010up, and are reported descriptively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 1281 patients were included in the registry (53.7% female). Mean age was 47.0 years. Of the patients, 793 and 231 completed the 2\u2010year follow\u2010up and 5\u2010year follow\u2010up, respectively. At baseline, 5.4% had changed or given up their job because of CHE, the average duration of CHE was 6.1 years, and, in 22.4%, the CHE was severe according to physician global assessment. Systemic treatment (alitretinoin, acitretin, and methotrexate) was prescribed at least once to 39.0% of the patients during the course of the follow\u2010up. Disease severity, quality of life and treatment satisfaction improved over time, and the proportion of patients receiving systemic treatments decreased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Under continued dermatological care, substantial improvements in disease severity and PROs over time was achieved during the course of the CARPE registry, even in patients with long\u2010standing and severe hand eczema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13113","type":"journal-article","created":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T08:58:37Z","timestamp":1537779517000},"page":"45-53","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Chronic hand eczema in Germany: 5\u2010year follow\u2010up data from the CARPE registry"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3805-8219","authenticated-orcid":false,"given":"Christian J.","family":"Apfelbacher","sequence":"first","affiliation":[{"name":"Medical Sociology, Institute of Epidemiology and Preventive Medicine University of Regensburg  Regensburg Germany"},{"name":"Department of Clinical Social Medicine Occupational and Environmental Dermatology, University Hospital, Ruprecht Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-6110","authenticated-orcid":false,"given":"Robert F.","family":"Ofenloch","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine Occupational and Environmental Dermatology, University Hospital, Ruprecht Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Department of Clinical Social Medicine Occupational and Environmental Dermatology, University Hospital, Ruprecht Karls University Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Molin","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Ludwig\u2010Maximilian\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Carl Gustav Carus, Technical University Dresden  Dresden Germany"},{"name":"Department of Dermatology, University Allergy Centre (UAC), University Hospital Carl Gustav Carus, Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Mahler","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital of Erlangen, Friedrich\u2010Alexander\u2010University Erlangen  Erlangen Germany"},{"name":"Allergology Division, Paul\u2010Ehrlich\u2010Institut  Langen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Heinrich","sequence":"additional","affiliation":[{"name":"Dermatological practice  Landsberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"von Kiedrowski","sequence":"additional","affiliation":[{"name":"Company for Medical Study &amp; Service Selters  Selters Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Centre for Evidence\u2010based Healthcare, Medical Faculty Carl Gustav Carus, Technical University Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7696-3274","authenticated-orcid":false,"given":"Peter","family":"Elsner","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Jena  Jena 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