{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:58:16Z","timestamp":1791197896258,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T00:00:00Z","timestamp":1540771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Knowledge about the skin deposition and penetration of nickel into the stratum corneum (SC) after short contact with metallic items is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To quantify nickel skin deposition and penetration into the SC after short contact with metallic nickel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen nickel\u2010allergic participants and 10 controls were exposed to 3 pure nickel discs and 1 aluminium disc on each volar forearm for 3\u2009\u00d7\u200910 minutes. Before exposure, 1 forearm was irritated with 0.5% sodium lauryl sulfate under 24\u2010hour occlusion. Immediately, as well as 24 and 72\u2009hours after metallic disc exposure, outer SC layers were removed with adhesive tapes and the nickel content was measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nickel deposition and SC penetration capable of eliciting allergic nickel dermatitis were found immediately and after 24\u2009hours. Significantly higher nickel amounts were found on normal skin and in the SC of nickel\u2010allergic participants than in controls both immediately and after 24 hours, and on irritated skin immediately after exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nickel deposition and SC penetration is considerable after nickel skin exposure of 3\u2009\u00d7\u200910 minutes. Combined with the allergic responses resulting from the same exposures reported previously, this study highlights that short skin exposure to nickel\u2010releasing items may cause allergic nickel dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13136","type":"journal-article","created":{"date-parts":[[2018,10,29]],"date-time":"2018-10-29T08:39:27Z","timestamp":1540802367000},"page":"86-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Nickel deposition and penetration into the stratum corneum after short metallic nickel contact: An experimental study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-7826","authenticated-orcid":false,"given":"Malin G.","family":"Ahlstr\u00f6m","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7160-4640","authenticated-orcid":false,"given":"Klara","family":"Midander","sequence":"additional","affiliation":[{"name":"Unit of Work Environment Toxicology Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-5896","authenticated-orcid":false,"given":"Carola","family":"Lid\u00e9n","sequence":"additional","affiliation":[{"name":"Unit of Work Environment Toxicology Institute of Environmental Medicine, Karolinska Institutet  Stockholm 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