{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T20:23:08Z","timestamp":1772223788985,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T00:00:00Z","timestamp":1542153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fragrance chemicals constitute the second most frequent cause of contact allergy in Spain. There are no data available concerning the individual fragrances that are most frequently involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the diagnostic contribution provided by specific fragrance series to the results obtained with baseline series fragrance markers by correlating the results of both series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We performed a 5\u2010year retrospective study of fragrance marker\u2010positive patients tested with specific fragrance series in 23 Spanish centres. We collected the demographic and clinical characteristics, and compared the results of patch tests obtained from different suppliers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 19\u2009588 patients patch tested with the Spanish baseline series, 1590 (8.1%) reacted positively to a fragrance marker. Of these, 1013 (63.7%) were patch tested with a fragrance series, and 664 patients reacted positively to at least one individual fragrance other than hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde. Geraniol was the most frequent allergen. Positive reactions to substances not included in fragrance mix (FM) I or FM II were found in 230 patients. Of the 436 FM I\u2010positive patients and the 419 FM II\u2010positive patients, 184 (42%) and 64 (39.1%), respectively, had no positive reactions to fragrance series. In the case of FM I, negative results were more common when individual fragrances were patch tested at low concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We recommend patch testing all patients positive for any fragrance marker with a specific fragrance series. The correlation between the results of baseline series and fragrance series could be improved by increasing the concentrations of individual fragrances.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13152","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T06:37:58Z","timestamp":1542263878000},"page":"94-100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Sensitization to fragrances in Spain: A 5\u2010year multicentre study (2011\u20102015)"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-6338","authenticated-orcid":false,"given":"Juan F.","family":"Silvestre","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante  Alicante 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Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Barcelona  Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda E.","family":"Gatica\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda A.","family":"Pastor\u2010NIeto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Guadalajara  Guadalajara Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Consorci Hospital Universitari de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose M.","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Garc\u00eda\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de la Macarena  Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Ruiz\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Insular de Gran Canaria  Las Palmas 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