{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:11Z","timestamp":1790520371975,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,13]],"date-time":"2018-11-13T00:00:00Z","timestamp":1542067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008392","name":"Sundhed og Sygdom, Det Frie Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Nickel allergy and dermatitis have been associated with filaggrin gene mutations in epidemiological studies, but the mechanisms mediating these associations are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate whether filaggrin\u2010deficient flaky tail (ft\/ft) mice show increased immune reactivity to nickel and elucidate the mechanisms mediating this.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The immune responses to nickel, 2,4\u2010dinitrofluorobenzene (DNFB), cinnamal and <jats:italic>p<\/jats:italic>\u2010phenylenediamine were assessed in ft\/ft and wild\u2010type (WT) mice. The amounts of nickel in the skin of ft\/ft and WT mice were determined 20\u2009hours after nickel exposure. The effect of blocking either the interleukin (IL)\u201017A pathway or the IL\u20101 pathway on the response to nickel in ft\/ft mice was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Increased responsiveness to nickel, DNFB and cinnamal was observed in ft\/ft mice as compared with controls. A reduced amount of nickel was found in the skin of ft\/ft mice as compared with WT mice, suggesting increased nickel absorption by the skin of ft\/ft mice. Blocking either the IL\u201017A pathway or the IL\u20101 pathway reduced nickel responsiveness in ft\/ft mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that the increased nickel responsiveness associated with epidermal filaggrin deficiency is mediated by a combination of increased nickel penetration and the steady\u2010state inflammation found in the skin of filaggrin\u2010deficient mice.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13153","type":"journal-article","created":{"date-parts":[[2018,11,14]],"date-time":"2018-11-14T06:54:38Z","timestamp":1542178478000},"page":"139-148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Mice with epidermal filaggrin deficiency show increased immune reactivity to nickel"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6587-7546","authenticated-orcid":false,"given":"Trine H.","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mia H.","family":"Jee","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy National Allergy Research Centre, Copenhagen University Hospital Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Sofie \u00d8.","family":"Gadsb\u00f8ll","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas 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