{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:00Z","timestamp":1790520360033,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Contact allergy to oxidized limonene, with hydroperoxides of limonene (Lim\u2010OOHs) as the main allergens, is common. However, high proportions of weak positive and doubtful patch test reactions have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the clinical relevance, elicitation threshold and dose\u2010response relationship of Lim\u2010OOHs in individuals with a positive or doubtful patch test reaction to standard Lim\u2010OOHs 0.3% pet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicentre 3\u2010week double\u2010blind vehicle\u2010controlled repeated open application test (ROAT) study with a simulated fine fragrance containing Lim\u2010OOHs at 1260, 420 and 140\u2009ppm, equal to a dose\/area per application of Lim\u2010OOHs of 3.0, 0.99 and 0.33\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>, was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 11 subjects allergic to Lim\u2010OOHs, 11 (100%), 7 (64%), and 3 (27%), respectively, reacted to the applied doses. No reactions were seen in 17 healthy controls exposed to the highest dose. This difference in reactivity was statistically significant (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Among 13 subjects with doubtful patch test reactions to Lim\u2010OOHs, two (15%) had positive ROAT reactions to the highest Lim\u2010OOH dose applied (<jats:italic>P<\/jats:italic>\u2009=\u20090.36 as compared with controls).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Contact allergy to Lim\u2010OOHs is of clinical relevance in patients with positive patch test reactions. A doubtful patch test reaction to Lim\u2010OOHs 0.3% pet. can be of clinical relevance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13168","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T02:23:31Z","timestamp":1540952611000},"page":"208-216","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Allergic contact dermatitis caused by hydroperoxides of limonene and dose\u2010response relationship\u2014A repeated open application test (ROAT) study"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8718-6140","authenticated-orcid":false,"given":"Niels H.","family":"Bennike","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Palangi","sequence":"additional","affiliation":[{"name":"Department of Occupational Dermatology Sahlgrenska University Hospital  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna Br\u00e5red","family":"Christensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"},{"name":"Department of Chemistry and Molecular Biology, Dermatochemistry and Skin Allergy University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrika","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry and Environmental Science Stockholm University  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9141-9215","authenticated-orcid":false,"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Occupational Dermatology Sahlgrenska University Hospital  Gothenburg Sweden"},{"name":"Department of Dermatology and Venereology Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg  Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01828.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14513"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12127"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01442.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12195"},{"key":"e_1_2_6_7_1","unstructured":"No author listed. 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