{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T13:18:32Z","timestamp":1788614312926,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Alkyl glucosides contitute a family of mild surfactants that are increasingly being used in a wide range of cosmetics and household products. Contact allergy to alkyl glucosides may be more frequent than previously suspected, especially in atopic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the frequency of contact allergy to alkyl glucosides, and to identify concomitant reactivity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively reviewed all cases of suspected allergic contact dermatitis (ACD) in which patients were patch tested with either a cosmetic series that includes five alkyl glucosides (decyl glucoside, lauryl glucoside, coco glucoside, cetearyl glucoside, and caprylyl\/capryl glucoside) or a specific alkyl glucoside series from November 2013 to April 2017 in two UK centres.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 5775 patients were patch tested across the two centres. Twenty\u2010nine (1.04%) of the 2796 patients tested with the cosmetic\/alkyl glucoside series had a positive patch test reaction to at least one of the alkyl glucosides. Twenty\u2010three (79.3%) patients were sensitized to multiple alkyl glucosides; 21 patients (72.4%) were female. The mean age was 43.5 years. Twelve patients (41.4%) had a background of atopic dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of alkyl glucoside\u2010induced ACD is relatively high, and there are frequent concomitant reactions between different alkyl glucosides. We recommend the inclusion of alkyl glucosides in all cosmetic series.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13186","type":"journal-article","created":{"date-parts":[[2018,11,21]],"date-time":"2018-11-21T07:54:11Z","timestamp":1542786851000},"page":"286-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-6882","authenticated-orcid":false,"given":"Bevin","family":"Bhoyrul","sequence":"first","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Solman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital  Leeds UK"},{"name":"Department of Dermatology Great Ormond Street Hospital for Children  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kirk","sequence":"additional","affiliation":[{"name":"SK\u2010CRS Ltd  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Orton","sequence":"additional","affiliation":[{"name":"152 Harley Street Ltd  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7253-3461","authenticated-orcid":false,"given":"Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BoydAH HylwaSA. Update on Alkyl Glucosides.https:\/\/www.the\u2010dermatologist.com\/article\/update\u2010alkyl\u2010glucosides?. 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