{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:41:07Z","timestamp":1790347267332,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Methylisothiazolinone (MI) is a preservative that is responsible for an epidemic of allergic contact dermatitis (ACD). Few studies have been published on the prognosis of patients with MI\u2010induced ACD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate relapses of MI\u2010induced ACD and difficulties in avoiding MI in patients who had received avoidance advice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of patients with MI\u2010induced ACD diagnosed in two specialized dermato\u2010allergology units between 2010 and 2015 was performed. The median follow\u2010up was 3 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Relapses were observed in 64% of 139 included patients, and were severe in 18%. Rinse\u2010off cosmetics were responsible for the largest proportion of relapses (27%). The median time to relapse was 5 months. Sixty\u2010nine per cent of relapses were on the hands, and 29% were on the face. Risk factors for relapsing were hand eczema and a personal history of atopy. The main difficulties encountered in the avoidance strategy were hidden sources of MI, the lack of labelling on industrial products, the complexity of cosmetic labelling, and remembering the name of the allergen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MI\u2010induced ACD has a poor prognosis. Its high rate of relapse is mainly attributable to the difficulties of avoidance. Management needs to be improved. Specialized follow\u2010up in the year following diagnosis is essential to educate patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13221","type":"journal-article","created":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T19:09:22Z","timestamp":1547752162000},"page":"304-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Methylisothiazolinone allergic contact dermatitis: Assessment of relapses in 139 patients after avoidance advice"],"prefix":"10.1111","volume":"80","author":[{"given":"Pauline","family":"Bouschon","sequence":"first","affiliation":[{"name":"Department of Dermatology, CHU Universit\u00e9 Clermont\u2010Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Waton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, CHU Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Luc","family":"Schmutz","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Universit\u00e9 de Lorraine Nancy France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine F.","family":"Le Bou\u00ebdec","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Universit\u00e9 Clermont\u2010Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6367-4227","authenticated-orcid":false,"given":"Michel","family":"D'Incan","sequence":"additional","affiliation":[{"name":"Department of Dermatology, CHU Universit\u00e9 Clermont\u2010Auvergne Clermont\u2010Ferrand France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12359"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12795"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.169"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12294"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12926"},{"key":"e_1_2_6_7_1","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1684\/ejd.2017.3156","article-title":"B\u2010cell lymphomatoid contact dermatitis caused by methylisothiazolinone and methylchloroisothiazolinone","volume":"28","author":"Smets K","year":"2018","journal-title":"Eur J Dermatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.13122"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000288"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12733"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12207"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01774.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12149"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12750"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13028"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12039"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000111"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12191"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000352"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12150"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-017-1803-0"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12590"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12068"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247217"},{"key":"e_1_2_6_26_1","unstructured":"Commission Regulation (EU) 2016\/1198 of 22 July 2016 amending Annex V to regulation (EC) No. 1223\/2009 of the European Parliament and of the Council on cosmetic products (Text with EEA relevance) [Internet]. 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