{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:44:25Z","timestamp":1772120665114,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Iodopropynyl butylcarbamate (IPBC) is a broad\u2010spectrum preservative for use in several product types, including cosmetics, in which its concentrations have been limited by EU legislation because of concerns related to its iodine content and release, and the risk of subsequent iodine overdose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report on concomitant patch test reactions observed with iodine and IPBC in patients sensitized to iodine\u2010containing antiseptics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>Between 2012 and 2018, seven patients, six from Belgium and one from France, two suffering from acute dermatitis during surgical interventions, four from dermatitis caused by wound treatment, and one from occupational dermatitis, were shown to be sensitized to iodine and\/or povidone\u2010iodine (PVP\u2010I), which was considered to be relevant for their dermatitis. All patients were coincidentally also patch tested with IPBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients showed positive patch test reactions to several other allergens, including IPBC. No relevance could be detected for IPBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suspect that, notwithstanding the absence of firm evidence for IPBC being dehalogenated to produce free iodine in animals or in humans, the patch test reactions to IPBC in iodine\u2010allergic subjects were possibly caused by free iodine released from this preservative agent, thus underlining the EU restrictions regarding the use of this preservative in cosmetics.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13224","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T08:19:05Z","timestamp":1548058745000},"page":"17-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Concomitant contact\u2010allergic reactions to iodopropynyl butylcarbamate and iodine"],"prefix":"10.1111","volume":"81","author":[{"given":"Charlotte","family":"Vanhoutte","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9805-3439","authenticated-orcid":false,"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-3104","authenticated-orcid":false,"given":"Liesbeth","family":"Gilissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Huygens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Vital\u2010Durand","sequence":"additional","affiliation":[{"name":"Service de Dermatologie H\u00f4pital Edouard\u2010Herriot  Lyon France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ella","family":"Dendooven","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp and University of Antwerp  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp and University of Antwerp  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1091581817717642"},{"key":"e_1_2_5_3_1","unstructured":"Food and Drug Administration (FDA). Substances for use only as components of adhesives 21 CFR 175.105.2013."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12109"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000097"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14063"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000373"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12062"},{"key":"e_1_2_5_9_1","unstructured":"Opinion of the SCCNFP concerning iodopropynyl butylcarbamate (P91). Adopted by the SCCNFP on 1 July 2004http:\/\/ec.europa.eu\/health\/ph_risk\/committees\/sccp\/...\/out288_en.pdf"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2198"},{"key":"e_1_2_5_11_1","first-page":"300","article-title":"Postsurgical contact dermatitis due to povidone iodine: a diagnostic dilemma","volume":"105","author":"de la Cuadra\u2010Oyangure J","year":"2014","journal-title":"Actas Dermosifiliogr"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13224","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13224","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13224","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:53:53Z","timestamp":1693828433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/cod.13224"],"URL":"https:\/\/doi.org\/10.1111\/cod.13224","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,19]]},"assertion":[{"value":"2018-12-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}