{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:42:07Z","timestamp":1761986527900,"version":"3.40.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Non\u2010steroidal anti\u2010inflammatory drugs constitute a main cause of fixed drug eruption (FDE). A few cases of piroxicam\u2010induced FDE have been reported; however, the cross\u2010reactivity among oxicams has rarely been evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe a series of patients with piroxicam\u2010induced FDE, mostly confirmed by a positive patch test reaction, in whom cross\u2010reactivity to meloxicam was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included all cases of piroxicam\u2010induced FDE diagnosed in the department of pharmacovigilance of Monastir. Patch tests for piroxicam and meloxicam were performed in the involved skin according to the European Network on Drug Allergy recommendations. Oral provocation tests (OPTs) were performed for patients with negative skin test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven patients were included in this study. FDE was multiple for five patients and solitary for two. Bullous eruption was noticed in two cases. Lesional patch tests for piroxicam gave positive results in six patients. To assess cross\u2010reactivity with meloxicam, this was patch tested. The test gave a positive result in only one patient. OPTs with meloxicam gave positive results in two patients with negative patch test results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Meloxicam is not a safe alternative for the treatment of piroxicam\u2010induced FDE, and OPTs can be used to confirm tolerance before this drug is prescribed as a safer alternative.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13225","type":"journal-article","created":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T08:29:30Z","timestamp":1548059370000},"page":"24-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Piroxicam\u2010induced fixed drug eruption: Cross\u2010reactivity with meloxicam"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5755-5117","authenticated-orcid":false,"given":"Haifa","family":"Ben Romdhane","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, EPS Fattouma Bourguiba University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-7243","authenticated-orcid":false,"given":"Helmi","family":"Ammar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, EPS Fattouma Bourguiba University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Najeh","family":"Ben Fadhel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, EPS Fattouma Bourguiba University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra","family":"Chadli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Pharmacology, EPS Fattouma Bourguiba University of Monastir  Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Ben 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