{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:54:10Z","timestamp":1747184050393,"version":"3.40.5"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is an ongoing discussion on whether routinely patch testing with <jats:italic>p<\/jats:italic>\u2010phenylenediamine (PPD) 1.0% pet. is safe, owing to the risk of patch test sensitization. Late\u2010appearing patch test reactions may reflect patch test sensitization, but may also be attributable to a low degree of pre\u2010existing sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To follow the positive patch test reactions to PPD and its salt PPD dihydrochloride (PPD\u2010DHC) in order to characterize reaction patterns concerning time and dose in PPD\u2010sensitized individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Volunteers with previous reactions to PPD 1.0% were included and patch tested with PPD and PPD\u2010DHC in equimolar dilution series. There were then seven follow\u2010up visits over a period of 28\u2009days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six volunteers completed the study, of whom 23 of 26 (88%) reacted to PPD 1.0%, and 69% reacted to PPD 0.32%. Altogether, 42% and 27% reacted to the corresponding equimolar concentrations of PPD\u2010DHC. After day 7, no new reactions were observed to any concentration tested, either of PPD or of PPD\u2010DHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>No late\u2010appearing reactions to PPD or PPD\u2010DHC were observed at any dose. There is a risk of missing contact allergy when the dose is decreased.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13235","type":"journal-article","created":{"date-parts":[[2019,1,26]],"date-time":"2019-01-26T08:43:21Z","timestamp":1548492201000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Twenty\u2010eight\u2010day follow\u2010up of patch test reactions to p\u2010phenylenediamine and p\u2010phenylenediamine dihydrochloride: A multicentre study on behalf of the European Environmental and Contact Dermatitis Research Group"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5172-8323","authenticated-orcid":false,"given":"Ewa","family":"Young","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-824X","authenticated-orcid":false,"given":"Klaus E.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, and Dermatological Investigations Scandinavia, Institute of Clinical Research, University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, IMIM, Universitat Aut\u00f2noma  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrine","family":"Ross\u2010Hansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob Torp","family":"Madsen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Centre Odense University Hospital, and Dermatological Investigations Scandinavia, Institute of Clinical Research, University of Southern Denmark  Odense Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Zimerson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Lund University, Sk\u00e5ne University Hospital  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"volume-title":"Aetiologie und Pthogenese der Ekzemkrankheiten. 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