{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:29:28Z","timestamp":1775478568621,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T00:00:00Z","timestamp":1553817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Isobornyl acrylate (IBOA) has recently been identified as one sensitizer in the FreeStyle Libre glucose sensor. Analyses with gas chromatography\u2010mass spectrometry (GC\u2010MS) have indicated the presence of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2010dimethylacrylamide (DMAA) in the sensor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>Seven patients were referred for patch testing after developing skin reactions when using FreeStyle Libre. All patients were patch tested with IBOA and DMAA. Two patients were tested with adhesive patches that had been removed from the sensors \u201cas is,\u201d and two patients were tested with acetone extracts of materials from the sensor. The extracts were analysed with GC\u2010MS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six patients reacted to both IBOA and DMAA, and one patient reacted only to DMAA. Positive reactions were also observed in both patients tested with the adhesive patch \"as is\". One patient reacted to both an extract of the adhesive patch and an extract of the sensor itself. When analysed with GC\u2010MS, IBOA was found in both extracts and DMAA was found in the extract of the sensor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both IBOA and DMAA may be present in adhesives used in medical devices such as glucose sensors or insulin pumps, and should be patch tested when suspected contact allergic reactions to these products are investigated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13243","type":"journal-article","created":{"date-parts":[[2019,2,18]],"date-time":"2019-02-18T08:34:24Z","timestamp":1550478864000},"page":"27-31","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["<i>N<\/i>,<i>N<\/i>\u2010dimethylacrylamide\u2014A new sensitizer in the FreeStyle Libre glucose sensor"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6172-9274","authenticated-orcid":false,"given":"Martin","family":"Mowitz","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7000-1672","authenticated-orcid":false,"given":"Anne","family":"Herman","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cliniques universitaires Saint\u2010Luc, Brussels, and IREC (Institut de Recherche Experimentale et Clinique) P\u00f4le Pneumologie, ORL, Dermatologie Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0499-7939","authenticated-orcid":false,"given":"Marie","family":"Baeck","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cliniques universitaires Saint\u2010Luc, Brussels, and IREC (Institut de Recherche Experimentale et Clinique) P\u00f4le Pneumologie, ORL, Dermatologie Universit\u00e9 Catholique de Louvain  Brussels Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annarita","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-7711","authenticated-orcid":false,"given":"Nils","family":"Hamnerius","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Pont\u00e9n","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,29]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12866"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12995"},{"key":"e_1_2_6_4_1","volume-title":"Manual of Contact Dermatitis","author":"Fregert S","year":"1981"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-199209000-00004"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12503"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000281"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12873"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296817738076"},{"key":"e_1_2_6_11_1","first-page":"440","volume-title":"Ullmann's Encyclopedia of Industrial Chemistry","author":"Onusseit H","year":"2012"},{"key":"e_1_2_6_12_1","unstructured":"Henkel Ltd. Safety Data Sheet according to Regulation (EC) No. 1907\/2006 LOCTITE AA 3311 LC known as 3311 Medical Adhesive Sweden.http:\/\/mymsds.henkel.com\/mymsds\/0006.232886.0194.en.MSDS_UT_GB.29462698.0.GB.pdf. Accessed November 22 2018."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1932296818762946"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045001054.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1982.tb04208.x"},{"key":"e_1_2_6_16_1","first-page":"181","article-title":"Allergic contact dermatitis from acrylamide in a chemical mixer","volume":"42","author":"Beyer DJ","year":"2000","journal-title":"Contact Dermatitis"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1988.tb02874.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01646.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.4706092.x"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb02473.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00142.x"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13243","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T11:54:39Z","timestamp":1693828479000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,29]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["10.1111\/cod.13243"],"URL":"https:\/\/doi.org\/10.1111\/cod.13243","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,29]]},"assertion":[{"value":"2018-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}