{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:26:51Z","timestamp":1787837211089,"version":"build-2784847793"},"reference-count":171,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:p>\n                    In this article, contact allergy to\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Myroxylon pereirae<\/jats:italic>\n                    <\/jats:styled-content>\n                    resin (MP) (balsam of Peru) is reviewed. The topics presented include the uses, the chemical composition, the frequency of sensitization, the relevance of positive reactions, the MP\u2010containing products causing allergic contact dermatitis, co\u2010reactivity with other fragrance and non\u2010fragrance materials, the sensitizers, the usefulness of MP as a \u201cmarker\u201d of fragrance allergy, and the effectiveness of, and indications for, \u201cbalsam\u2010restrictive\u201d diets. Sensitization to MP occurs in 4% to 8% of patients routinely tested for suspected contact dermatitis. There are few adequate data on relevance. Topical pharmaceuticals were formerly, but are not today, important sources of sensitization. Cosmetics and foods or drinks are hardly ever products responsible for sensitization to MP. Positive patch test reactions in the large majority probably result from previous sensitization to MP constituents because of their presence in fragrances and fragranced products, MP thereby acting as marker (or \u201cindicator\u201d) of fragrance allergy. However, fragrance mix I is a more sensitive marker, and the added diagnostic value of testing with MP is unknown. The allergenic ingredients of MP include isoeugenol, eugenol and cinnamyl alcohol, but there are other\u2014largely unknown\u2014chemicals that are responsible for contact allergy. Suggestions are given for further research to address questions thus far unanswered and to improve patient care.\n                  <\/jats:p>","DOI":"10.1111\/cod.13263","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T01:15:06Z","timestamp":1551921306000},"page":"335-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["<i>Myroxylon pereirae<\/i>\n                    resin (balsam of Peru) \u2013 A critical review of the literature and assessment of the significance of positive patch test reactions and the usefulness of restrictive diets"],"prefix":"10.1111","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6666-7292","authenticated-orcid":false,"given":"Anton C.","family":"de Groot","sequence":"first","affiliation":[{"name":"acdegroot publishing Wapserveen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"153","volume-title":"Aethiologie und Pathogenese der Ekzemkrankheiten","author":"Bonnevie P","year":"1939"},{"issue":"46","key":"e_1_2_11_3_1","first-page":"1","article-title":"Eczematous allergy to balsams","volume":"41","author":"Hjorth N","year":"1961","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1982.tb02379.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1968.01610100057008"},{"key":"e_1_2_11_6_1","volume-title":"Monographs in Contact Allergy, Volume II\u2014Fragrances and Essential Oils","author":"de Groot AC","year":"2019"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/1046-199X(95)90043-8"},{"key":"e_1_2_11_8_1","unstructured":"MammerlerV. 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