{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:40:49Z","timestamp":1770489649718,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T00:00:00Z","timestamp":1561248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metal allergies are the most frequent causes of allergic contact dermatitis. Although the use of palladium is increasing, it is not included in any baseline series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the prevalence of hypersensitivity to palladium and to describe the clinical and demographic characteristics of patients who are sensitized to palladium dichloride (PdCl<jats:sub>2<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A single\u2010centre, retrospective study of 15\u2009years of patch testing with the Spanish baseline series supplemented with PdCl<jats:sub>2<\/jats:sub>2% pet. was performed. We collected clinical and demographic data and data on co\u2010sensitization among the metals studied, and we compared patients who were sensitized to palladium, with or without co\u2010sensitization to nickel, with the rest of the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 3678 included patients, 730 (19.9%) were sensitized to nickel sulfate. The prevalence of sensitization to PdCl<jats:sub>2<\/jats:sub>(<jats:italic>n<\/jats:italic>= 316, 8.6%) was higher than the prevalence of sensitization to potassium dichromate (n = 240, 6.5%) and similar to the prevalence of sensitization to cobalt chloride (n = 353, 9.6%). Only 26 (8.2%) of the patients sensitized to palladium were not co\u2010sensitized to nickel. The percentage of men and patients aged \u226540\u2009years was higher in this subgroup than in the patients with nickel co\u2010sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Given the high prevalence of hypersensitivity to PdCl<jats:sub>2<\/jats:sub>, this metal salt should be included in the Spanish baseline series, notwithstanding the frequency of co\u2010sensitization to nickel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13343","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T05:44:22Z","timestamp":1561355062000},"page":"249-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Delayed hypersensitivity to palladium dichloride: 15\u2010year retrospective study in a skin allergy unit"],"prefix":"10.1111","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1384-6991","authenticated-orcid":false,"given":"Luc\u00eda","family":"Gonz\u00e1lez\u2010Ruiz","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Ciudad Real Ciudad Real Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Vergara De Caso","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Pe\u00f1a\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan F.","family":"Silvestre\u2010Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1111\/ddg.12673","article-title":"Immunology of metal allergies","volume":"13","author":"Schmidt M","year":"2015","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12846"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20186047"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/cod.12582","article-title":"ESSCA results with nickel, cobalt and chromium, 2009\u20102012","volume":"75","author":"Uter W","year":"2016","journal-title":"Contact 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