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Exposure to all <jats:italic>n<\/jats:italic>\u2010propanol concentrations significantly reduced the NMF levels. Preceding low\u2010grade trauma by occlusion\/water exposure reduced the skin irritation threshold in both groups. The differences in the severity of the barrier function impairment after exposure to the same concentrations under the same conditions between the AD and control groups were significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The negative effects of cumulative exposure to <jats:italic>n<\/jats:italic>\u2010propanol in healthy and atopic skin shown in the study suggest the need for critical re\u2010evaluation of its irritant properties <jats:italic>in vivo<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13368","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T12:15:12Z","timestamp":1564748112000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Barrier damaging effects of <i>n<\/i>\u2010propanol in occlusion\u2010modified tandem repeated irritation test: Modulation by exposure factors and atopic skin disease"],"prefix":"10.1111","volume":"82","author":[{"given":"Irena","family":"Angelova\u2010Fischer","sequence":"first","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology Kepler University Hospital  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Soltanipoor","sequence":"additional","affiliation":[{"name":"Coronel Institute of Occupational Health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasja","family":"Stilla","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias W.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of L\u00fcbeck  L\u00fcbeck Germany"},{"name":"Department of Dermatology Kepler University Hospital  Linz Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanja","family":"Kezic","sequence":"additional","affiliation":[{"name":"Coronel Institute of Occupational Health, Amsterdam UMC, Amsterdam Public Health Research Institute University of Amsterdam  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-4069","authenticated-orcid":false,"given":"Ivone","family":"Jakasa","sequence":"additional","affiliation":[{"name":"Laboratory for Analytical Chemistry, Department of Chemistry and Biochemistry, Faculty of Food Technology and Biotechnology University of Zagreb  Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,7]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Alcohol Sanitizer","author":"Gold NA","year":"2018"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.4.863-893.2004"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06875.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12981"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2363"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb08530.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(79)70001-6"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00921.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1990.tb01553.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000056341"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00174.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1815"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00032719.2013.789881"},{"key":"e_1_2_6_15_1","unstructured":"BAUA: Federal Institute for Occupational Health; TRGS 401 Risks Resulting from Skin Contact \u2013 Identification Assessment Measures 2011.https:\/\/www.baua.de\/EN\/Service\/Legislative-texts-and-technical-rules\/Rules\/TRGS\/pdf\/TRGS-401.pdf?__blob=publicationFile&v=2. 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