{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T17:38:12Z","timestamp":1779903492222,"version":"3.53.1"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Since 2009, an increasing number of published cases of allergic contact dermatitis (ACD) from isothiazolinones in Europe was observed, amounting to an epidemic. However, only few studies have assessed the current situation after changes in European regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the incidence of isothiazolinone\u2010related ACD in our area in the last decade.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study analyzed all patients patch tested in the allergy unit in a tertiary hospital in Spain between January 2010 and June 2019. Positive patch\u2010test reactions to methylchloroisothiazolinone (MCI)\/methylisothiazolinone (MI) and\/or MI alone were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 243 patients (9.55%) with positive patch\u2010test reactions to MCI\/MI and\/or MI alone among 2544 consecutively patch\u2010tested patients were recorded. An initial increase in the prevalence of MCI\/MI allergy was observed, from 4.5% in 2010 reaching a peak in 2015, which was followed by a significant decrease until July 2019 with 3.1% prevalence in 2019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>As shown in our data, regulatory interventions have resulted in a dramatic decrease in the prevalence of MCI and MI ACD, reaching a pre\u2010epidemic level of 3.1% in 2019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13396","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T07:24:30Z","timestamp":1568359470000},"page":"83-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Contact allergy to isothiazolinones epidemic: Current situation"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0046-6962","authenticated-orcid":false,"given":"Jorge","family":"Magdaleno\u2010Tapial","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Valenzuela\u2010O\u00f1ate","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5472-3974","authenticated-orcid":false,"given":"Jos\u00e9 M.","family":"Ortiz\u2010Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Garc\u00eda\u2010Legaz\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1lvaro","family":"Mart\u00ednez\u2010Domenech","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Alonso\u2010Carpio","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Sierra Talamantes","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"Zaragoza\u2010Ninet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Zaragoza\u2010Ninet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"854","article-title":"Descriptive study of sensitization to methylchloroisothiazolinone and methylisothiazolinone in a skin allergy unit","volume":"105","author":"Unamuno B","year":"2014","journal-title":"Actas 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