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Filaggrin gene (<jats:italic>FLG<\/jats:italic>) mutations are known to result in dry skin, impaired skin barrier, and increased risk for atopic dermatitis. However, it is not clear whether these mutations are associated with contact allergy or hand eczema in adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of this study was to investigate whether <jats:italic>FLG<\/jats:italic> mutations are associated with contact allergy, self\u2010reported hand eczema, or dry skin in adolescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used data from the 16\u2010year follow\u2010up in the BAMSE cohort, information obtained from a Web\u2010based questionnaire including questions on hand eczema and dry skin, from <jats:italic>FLG<\/jats:italic> mutation analysis (R501X, R2447X, 2282del4), and patch testing (n = 1822).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Logistic regression analyses showed no statistically significant associations between <jats:italic>FLG<\/jats:italic> mutations and contact allergy (any contact allergy, nickel allergy, or fragrance allergy) according to patch test, or self\u2010reported hand eczema at 16\u2009years, or hand eczema ever. However, <jats:italic>FLG<\/jats:italic> mutations were associated with self\u2010reported dry skin at 16\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>FLG<\/jats:italic> mutations are associated with self\u2010reported dry skin at 16\u2009years. However, in this study no consistent associations were found between <jats:italic>FLG<\/jats:italic> mutations and contact allergy or hand eczema at 16.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13444","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T04:03:10Z","timestamp":1575000190000},"page":"147-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Filaggrin gene mutations in relation to contact allergy and hand eczema in adolescence"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8506-4577","authenticated-orcid":false,"given":"Maria","family":"Lagrelius","sequence":"first","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"},{"name":"Region Stockholm Centre for Occupational and Environmental Medicine  Stockholm 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