{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T00:51:58Z","timestamp":1770598318490,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recurrent vesicular hand eczema frequently has a chronic course and needs long\u2010term treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate health\u2010related quality of life (HRQoL), treatment satisfaction, and adherence in patients with vesicular hand eczema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients using one main treatment for at least three\u2009months were included. Data on HRQoL (Quality of Life in Hand Eczema Questionnaire [QOLHEQ]), treatment satisfaction (Treatment Satisfaction Questionnaire for Medication, version II), and treatment adherence (4\u2010item Morisky Medication Adherence Scale) were collected. Univariate and multivariate regression analysis were used to predict variables associated with HRQoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HRQoL was moderately impaired, with the highest impact in the QOLHEQ subdomain symptoms. Female sex, more severe hand eczema, and lower treatment satisfaction were associated with more impairment in HRQoL. Patients with severe\/very severe hand eczema had significant lower \u201cglobal satisfaction\u201d scores compared with the other severity groups. The \u201cglobal satisfaction\u201d and treatment adherence in patients using systemic treatment were significantly higher compared with those with only topical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with vesicular hand eczema disease severity affects both HRQoL and treatment satisfaction. Systemic treatment of severe hand eczema could improve the severity and as a result also HRQoL, treatment satisfaction, and medication adherence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13459","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T01:31:22Z","timestamp":1577496682000},"page":"201-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quality of life, treatment satisfaction, and adherence to treatment in patients with vesicular hand eczema: A cross\u2010sectional study"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6475-6876","authenticated-orcid":false,"given":"Klaziena","family":"Politiek","sequence":"first","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-6110","authenticated-orcid":false,"given":"Robert F.","family":"Ofenloch","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Occupational Dermatology University Hospital Heidelberg, Occupational and Environmental Dermatology  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marius J.","family":"Angelino","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9410-2838","authenticated-orcid":false,"given":"Ewoud","family":"van den Hoed","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Groningen, University of Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L. 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