{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T10:33:37Z","timestamp":1781174017069,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibiotics have been implicated in the reactivation of exanthema and systemic involvement in drug reaction with eosinophilia and systemic symptoms (DRESS); however, it is not clear whether these patients become sensitized to the antibiotic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate if, after DRESS, patients become sensitized to antibiotics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the patch test (PT) data and clinical files of DRESS patients who were administered antibiotics during DRESS from other culprits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine patients out of 17 (53%) were positive to antibiotics in PT: six to the penicillin group and three to cephalosporins (including one patient with additional positivity to vancomycin). Considering the eight patients who were negative to antibiotics in PT, seven were exposed to a fluoroquinolone. Four cases were patch tested again and three remained positive to antibiotics 2 to 5\u2009years thereafter. Two patients with positive PT results had an accidental re\u2010exposure to antibiotics and developed a maculopapular exanthema without systemic symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to antibiotics during DRESS or its prodromal phase could enhance sensitization to antibiotics, as confirmed by a positive PT. Reproducibility of positive PTs to antibiotics after several years and reactivation after re\u2010exposure support that T\u2010cell\u2010mediated hypersensitivity to antibiotics in the setting of DRESS is a specific reaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13462","type":"journal-article","created":{"date-parts":[[2020,1,4]],"date-time":"2020-01-04T07:14:40Z","timestamp":1578122080000},"page":"290-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Hypersensitivity to antibiotics in drug reaction with eosinophilia and systemic symptoms (DRESS) from other culprits"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2587-5535","authenticated-orcid":false,"given":"Luis G.","family":"Santiago","sequence":"first","affiliation":[{"name":"Department of Dermatology Coimbra University Hospital  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-4334","authenticated-orcid":false,"given":"Francisca J.","family":"Morgado","sequence":"additional","affiliation":[{"name":"Department of Dermatology Coimbra University Hospital  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-615X","authenticated-orcid":false,"given":"Mariana S.","family":"Baptista","sequence":"additional","affiliation":[{"name":"Department of Dermatology Coimbra University Hospital  Coimbra Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6842-1360","authenticated-orcid":false,"given":"Margarida","family":"Gon\u00e7alo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Coimbra University Hospital  Coimbra Portugal"},{"name":"Faculty of Medicine University of Coimbra  Coimbra 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