{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:41:12Z","timestamp":1756190472225,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T00:00:00Z","timestamp":1583884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Concerns have been raised that a chronic course of hand eczema (HE) could be fostered by a lack of efficient treatment at an early stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>First, to assess the prevalence of systemic treatment in patients with chronic occupational HE (OHE) and relate this to demographic data, HE severity, and atopic dermatitis (AD). Second, to explore the use of complementary and alternative medicine (CAM) in the same population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Baseline data were obtained from a registry\u2010based study including patients with recognized OHE in a 2\u2010year period in Denmark, comprising a total of 2703 workers. A follow\u2010up questionnaire after 4 to 5\u2009years included questions on disease severity and treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1565 participants responded to the questionnaire, and of these 1203 had ongoing HE at follow\u2010up and were included in the study. In total, 10.0% had received systemic therapy, whereas this share was 13.3% in those with self\u2010reported moderate\u2010to\u2010severe HE. Age &gt;35\u2009years, previous or current AD, and severe eczema were factors related to use of systemic treatment. Use of CAM was reported by 6.2% of the study population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We suggest that chronicity of HE may be perpetuated by the lack of efficient treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13477","type":"journal-article","created":{"date-parts":[[2020,1,22]],"date-time":"2020-01-22T12:00:52Z","timestamp":1579694452000},"page":"272-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systemic therapy and the use of complementary and alternative medicine in patients with recognized occupational hand eczema in Denmark: A cross\u2010sectional questionnaire\u2010based study"],"prefix":"10.1111","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4279-0149","authenticated-orcid":false,"given":"Farnam","family":"Barati Sedeh","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels E.","family":"Ebbeh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg University Hospital  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja K.","family":"Car\u00f8e","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg University Hospital  Copenhagen Denmark"},{"name":"National Research Centre for the Working Environment  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12510_1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2004.00423.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12134"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00731.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2007.01179.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.3.305"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01345.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09402.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1104084"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16062"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.04001.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00159.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12869"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1632"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13113"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14974"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15451"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12614"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02170.x"},{"key":"e_1_2_6_21_1","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2340\/0001555570421424","article-title":"Use 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