{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T17:27:28Z","timestamp":1774632448806,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methylchloroisothiazolinone\/methylisothiazolinone (MCI\/MI) and methylisothiazolinone (MI) are tested to detect contact allergy to these isothiazolinones.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study if an aqueous patch test preparation with MCI and MI in a mix of 0.015% and 0.2%, respectively, detects more contact allergies than the commonly used preparations of MCI\/MI in 0.02% aq. and MI in 0.2% aq.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1555 patients with dermatitis in five Swedish dermatology departments were tested consecutively with MCI\/MI 0.215% aq., MCI\/MI 0.02% aq., and MI 0.2% aq.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The share of contact allergy to MCI\/MI 0.215% aq., MCI\/MI 0.02% aq., and MI 0.2% aq. varied in the test centers between 7.9% and 25.9%, 3.2% and 10.3%, and 5.8% and 12.3%, respectively. MCI\/MI 0.215% aq. detected significantly more patch\u2010test positive individuals than both MCI\/MI 0.02% aq. (<jats:italic>P<\/jats:italic> &lt;\u2009.001) and MI 0.2% aq. (<jats:italic>P<\/jats:italic> &lt;\u2009.001), as well as either one of MCI\/MI and MI (<jats:italic>P<\/jats:italic> &lt;\u2009.001). In the patients only reacting to MCI\/MI 0.215% aq., 57.7% were recorded as having a dermatitis that was explained or aggravated by exposure to either MCI\/MI or MI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results speak in favor of replacing the preparations MCI\/MI 0.02% aq. and MI 0.2% aq. with MCI\/MI 0.215% aq. as the screening substance in the Swedish baseline series, which has been implemented in 2020.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13483","type":"journal-article","created":{"date-parts":[[2020,2,29]],"date-time":"2020-02-29T06:58:34Z","timestamp":1582959514000},"page":"283-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Can patch testing with methylchloroisothiazolinone\/methylisothiazolinone be optimized using a new diagnostic mix? \u2013 A multicenter study from the Swedish Contact Dermatitis Research Group"],"prefix":"10.1111","volume":"82","author":[{"given":"Malin","family":"Engfeldt","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-0962","authenticated-orcid":false,"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johanna","family":"Br\u00e5red\u2010Christensson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"},{"name":"Dermatochemistry, Department of Chemistry and Molecular Biology University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Hagvall","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sahlgrenska Academy at the University of Gothenburg  Gothenburg Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mih\u00e1ly","family":"Matura","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skaraborgs Hospital  Sk\u00f6vde Sweden"},{"name":"Institute of Environmental Medicine, Karolinska Institutet and Centre for Occupational and Environmental Medicine  Stockholm Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina","family":"Ryberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology Region V\u00e4stra G\u00f6taland, NU Hospital Group  Uddevalla Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berndt","family":"Stenberg","sequence":"additional","affiliation":[{"name":"Department of Public Health and Clinical Medicine, Dermatology and Venereology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University  Malm\u00f6 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,20]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"283","volume-title":"Exogenous Dermatoses","author":"Bruze 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