{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:35:55Z","timestamp":1792172155973,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001663","name":"Volkswagen Foundation","doi-asserted-by":"publisher","award":["ZN2778"],"award-info":[{"award-number":["ZN2778"]}],"id":[{"id":"10.13039\/501100001663","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Metal work apprentices (MWAs) frequently develop work\u2010related hand eczema (HE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of health education on incidence of work\u2010related HE in MWAs and to assess confounding factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/methods<\/jats:title><jats:p>In a prospective controlled intervention study, 131 MWAs received educational training on prevention of HE, whereas 172 MWAs and 118 office work apprentices served as controls. At baseline and during three yearly follow\u2010ups, questionnaires were completed and hands were examined. Saliva samples were collected for assessment of filaggrin (<jats:italic>FLG<\/jats:italic>) null mutations and an explorative genome\u2010wide association study (GWAS), and levels of various cytokines were assessed from stratum corneum samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 2\u2010year and 3\u2010year incidence of HE in the metalwork control group was 20.9% and 32.6%, respectively, which was significantly higher than in the intervention group (odds ratio [OR] 2.63, 95% confidence interval [CI] 1.31 to 5.28, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01 and OR 3.47, 95% CI 1.88 to 6.40, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). The knowledge score was higher in unaffected MWAs (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Other factors significantly associated with developing HE in MWAs were smoking cigarettes (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) and <jats:italic>FLG<\/jats:italic> mutations (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). No significant associations were found regarding epidermal cytokine levels and GWAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Health education is effective in primary prevention of HE in MWAs. Individual factors should be considered in targeted counseling.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13502","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T05:17:40Z","timestamp":1582694260000},"page":"350-360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Health education decreases incidence of hand eczema in metal work apprentices: Results of a controlled intervention study"],"prefix":"10.1111","volume":"82","author":[{"given":"Anna","family":"Reich","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-0449","authenticated-orcid":false,"given":"Annika","family":"Wilke","sequence":"additional","affiliation":[{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm), University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnther","family":"Gediga","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck 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