{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T16:28:05Z","timestamp":1774628885005,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,3,25]],"date-time":"2020-03-25T00:00:00Z","timestamp":1585094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Europe, contact photosensitivity to phenothiazines is well\u2010known, particularly in southern countries. Topical phenothiazines are widely used and sold over\u2010the\u2010counter (OTC) for the treatment of mosquito bites and pruritus in France.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report a series of cases with photodermatitis following use of topical phenothiazines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study of cases of contact dermatitis from phenothiazines seen in French photodermatology centers was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 14 patients with a diagnosis of contact dermatitis from phenothiazines were included. These patients developed eczema on the application sites, and in 13 the eruption spread to photodistributed sites. Topical products containing isothipendyl were the most common cause of photodermatitis. One patient had photoaggravated eczema due to promethazine cream. All patients stopped using topical phenothiazines and were treated successfully with topical corticosteroids. One patient relapsed and developed persistent light eruption. In all of the nine cases tested, photopatch testing to the topical phenothiazine used \u201cas is\u201d was positive. Isothipendyl, chlorproethazine, and the excipients were not tested. Photopatch tests to chlorpromazine and promethazine were positive in 8 of 12 and 7 of 13 tested, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Use of isothipendyl and promethazine as OTC (or even prescribed) drugs needs to be limited due to severe reactions and sensitization to other phenothiazines that consequently will have to be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13509","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T03:23:31Z","timestamp":1583205811000},"page":"19-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Photodermatitis from topical phenothiazines: A case series"],"prefix":"10.1111","volume":"83","author":[{"given":"Claire","family":"Cariou","sequence":"first","affiliation":[{"name":"Department of Dermatology CHU Pontchaillou  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Droitcourt","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Pontchaillou  Rennes France"},{"name":"EA 7449 REPERES Pharmacoepidemiology and Health Services Research  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Noelle","family":"Osmont","sequence":"additional","affiliation":[{"name":"Centre of Pharmacovigilance CHU Pontchaillou  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie Claude","family":"Marguery","sequence":"additional","affiliation":[{"name":"Department of Dermatology Larrey Hospital, Paul Sabatier University  Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Dutartre","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Hotel Dieu  Nantes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliette","family":"Delaunay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Angers University Hospital  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martine","family":"Avenel\u2010Audran","sequence":"additional","affiliation":[{"name":"Department of Dermatology Angers University Hospital  Angers France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Dupuy","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Pontchaillou  Rennes France"},{"name":"EA 7449 REPERES Pharmacoepidemiology and Health Services Research  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9117-9306","authenticated-orcid":false,"given":"Henri","family":"Adamski","sequence":"additional","affiliation":[{"name":"Department of Dermatology CHU Pontchaillou  Rennes France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05817.x"},{"issue":"2","key":"e_1_2_6_3_1","first-page":"96","article-title":"Results and assessment of photopatch testing in Spain: towards a new standard set of photoallergens","volume":"98","author":"Cuadra\u2010Oyanguren J","year":"2007","journal-title":"Actas Dermosifiliogr"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463200802100327"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01550.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.044006366-8.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79275-9"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000338024"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04452.x"},{"key":"e_1_2_6_10_1","unstructured":"ANSM Agence nationale de s\u00e9curit\u00e9 du m\u00e9dicament et des produits de sant\u00e9. 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