{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:12:50Z","timestamp":1791443570592,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T00:00:00Z","timestamp":1592352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The resistant and recalcitrant nature of severe allergic contact dermatitis (ACD) makes its management challenging. With advances in the understanding of the cellular and molecular pathogenesis of ACD, newer therapeutic targets are becoming apparent. In particular, the use of biologics has gained momentum, given the specificity of their action. This article aims to review the presently available data on the use of biologics in ACD. English\u2010language\u2013based literature available on the use of biological therapy was thoroughly probed in the following databases as on October 14, 2019: PubMed, Google Scholar, The Cochrane library, Embase, Scopus, and EBSCO. The following keywords were used: \u201ccontact dermatitis\u201d, \u201callergens\u201d, \u201cdelayed\u2010type hypersensitivity reaction\u201d, \u201cbiologics\u201d, \u201cbiological therapy\u201d, \u201cmonoclonal antibodies\u201d, \u201cpatch testing\u201d, \u201cTNF\u2010\u03b1 inhibitors\u201d, \u201cinfliximab\u201d, \u201cadalimumab\u201d, \u201cetanercept\u201d, \u201cdupilumab\u201d, \u201comalizumab\u201d, \u201csecukinumab\u201d, \u201custekinumab\u201d, \u201crituximab\u201d.<\/jats:p>","DOI":"10.1111\/cod.13584","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T14:15:03Z","timestamp":1588169703000},"page":"179-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Review of biologics in allergic contact dermatitis"],"prefix":"10.1111","volume":"83","author":[{"given":"Jushya","family":"Bhatia","sequence":"first","affiliation":[{"name":"Department of Dermatology Sarin Skin Solutions  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankur","family":"Sarin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Sarin Skin Solutions  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Wollina","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology, St\u00e4dtisches Klinikum Dresden Academic Teaching Hospital of the Technical University of Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Studies Guglielmo Marconi  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Navarini","sequence":"additional","affiliation":[{"name":"Department of Dermatology &amp; Allergy University Hospital of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon M.","family":"Mueller","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Saloga","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center Mainz  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghasem R.","family":"Rokni","sequence":"additional","affiliation":[{"name":"Associate Professor of Dermatology, Department of Dermatology Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Basel  Basel Switzerland"},{"name":"Department of Dermatology University Medical Center Mainz  Mainz Germany"},{"name":"Department of Dermatology University of Rome G. Marconi  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.02.1144"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04031.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.3.673"},{"issue":"1","key":"e_1_2_6_5_1","first-page":"103","article-title":"Subcutaneous perfusion of tumour necrosis factorinduces local proliferation of fibroblasts, capillaries, and epidermal cells, or massive tissue necrosis","volume":"136","author":"Piguet PF","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.016"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.003"},{"issue":"7","key":"e_1_2_6_8_1","first-page":"1356","article-title":"Pneumococcal vaccine response in psoriatic arthritis patients during treatment with etanercept","volume":"31","author":"Mease PJ","year":"2004","journal-title":"J Rheumatol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000056"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/205873920601900125"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01695.x"},{"key":"e_1_2_6_12_1","first-page":"718","volume-title":"Janeway's Immunobiology","author":"Murphy K","year":"2012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1999.00550.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200105)31:5<1582::AID-IMMU1582>3.0.CO;2-M"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1998.tb05634.x"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1996.tb02303.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1610020"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000409"},{"issue":"6","key":"e_1_2_6_19_1","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/DER.0000000000000414","article-title":"Dupilumab as a treatment for allergic contact dermatitis","volume":"29","author":"Chipalkatti N","year":"2018","journal-title":"Dermatitis"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.043"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000346"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13134"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000357"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200161020-00008"},{"issue":"4","key":"e_1_2_6_25_1","first-page":"287","article-title":"Occupational wheat contact dermatitis and treatment with omalizumab","volume":"23","author":"Mur Gimeno P","year":"2013","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01592.x"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-202371"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.09.036"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12043"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12988"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.3.6.17815"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901767"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01907.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.06.033"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2006.02330.x"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2018.09.008"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:40:21Z","timestamp":1693910421000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,17]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/cod.13584"],"URL":"https:\/\/doi.org\/10.1111\/cod.13584","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,17]]},"assertion":[{"value":"2020-04-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}