{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T20:51:34Z","timestamp":1777927894653,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Occupational contact urticaria due to inhalation of legume pest allergens has rarely been described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine the cause of an outbreak of airborne contact urticaria, asthma, and anaphylaxis in farmers and agronomists studying the disinsectization of dried peas. Peas were treated with aluminum phosphide (EPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Extracts prepared from <jats:italic>Bruchus lentis<\/jats:italic> and <jats:italic>Bruchus pisorum<\/jats:italic> bodies and from healthy legumes, EPA\u2010treated legumes, and infested legumes, were used for in vivo tests (skin prick testing, oral, and specific bronchial challenge for the diagnosis of asthma and anaphylaxis) in affected patients and in five control patients with severe legume hypersensitivity. Open application, patch testing with the most common legume insecticides, molecular analysis, and IgE immunoblotting were undertaken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found positive responses (prick, provocation, immune detection) to parasitic pea extracts and <jats:italic>B. pisorum.<\/jats:italic> A 25 kDa band was detected in the western blot of all patients who worked with infested EPA\u2010treated peas. Bands from <jats:italic>B. pisorum<\/jats:italic> extract were detected in all patients. No responses to pea allergens were found in any patient, unlike in legume allergy controls. Oral provocation tests were negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>B. pisorum<\/jats:italic> is a cause of contact urticaria and may cause occupational hives, anaphylaxis, and asthma. The allergen may enter by inhalation or puncture of setae released by <jats:italic>B. pisorum<\/jats:italic>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13644","type":"journal-article","created":{"date-parts":[[2020,6,27]],"date-time":"2020-06-27T10:28:14Z","timestamp":1593253694000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Occupational airborne contact urticaria, anaphylaxis and asthma in farmers and agronomists due to <scp><i>Bruchus pisorum<\/i><\/scp>"],"prefix":"10.1111","volume":"83","author":[{"given":"Alicia","family":"Armentia","sequence":"first","affiliation":[{"name":"Allergy Unit Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Alvarez","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Molecular \u00c1rea de Biolog\u00eda Celular, Universidad de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0094-1559","authenticated-orcid":false,"given":"V\u00edctor","family":"Moreno\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Departamento de Biodiversidad y Gesti\u00f3n Ambiental \u00c1rea de Zoolog\u00eda, Universidad de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Allergy Unit Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Allergy Unit Hospital Universitario R\u00edo Hortega  Valladolid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Allergy Unit Hospital Universitario R\u00edo 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