{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:45:17Z","timestamp":1762659917623,"version":"3.40.5"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fixed drug eruption (FDE) is a characteristic form of intraepidermal CD8<jats:sup>+<\/jats:sup> T cell\u2010mediated drug reaction, with repeated appearance of isolated or multiple skin lesions in the same location after receiving the offending drug. Non\u2010steroidal anti\u2010inflammatory drugs (NSAID) are the most common cause. Selective inhibitors of inducible cyclooxygenase 2 (COX\u20102) provoke a lesser degree of allergic or idiosyncratic adverse reactions than conventional NSAID, but they can cause skin reactions of variable severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Etoricoxib has been related to a variety of unusual skin reactions, including several reports of FDE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We perfomed epicutaneous test to diagnose patients with suspected etoricoxib fixe drug rash due to clinical features and reproducibility on at least two occasions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We present seven new cases of etoricoxib\u2010induced fixed drug eruption, with a diagnosis based on clinical presentation. This diagnosis was confirmed by an etoricoxib\u2010positive lesional patch test in six cases and by a positive low\u2010dose oral challenge in the other one. Two patients showed negative patch tests with celecoxib (10% in pet.) on the residual lesions, and oral tolerance was confirmed in one.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>To our knowledge, this is the largest series on FDE induced by etoricoxib reported to date.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13659","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:41:58Z","timestamp":1594798918000},"page":"192-195","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Etoricoxib\u2010induced fixed drug eruption: Report of seven cases"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5696-7638","authenticated-orcid":false,"given":"Maria Dolores","family":"Mart\u00ednez Ant\u00f3n","sequence":"first","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Cruces  Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Gal\u00e1n Gimeno","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Cruces  Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"S\u00e1nchez de Vicente","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Cruces  Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-7246","authenticated-orcid":false,"given":"Ignacio","family":"J\u00e1uregui Presa","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Cruces  Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro M.","family":"Gamboa Seti\u00e9n","sequence":"additional","affiliation":[{"name":"Servicio de Alergia Hospital Universitario Cruces  Barakaldo Bizkaia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13351"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026617666170821124947"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1592\/phco.24.9.856.36106"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01982.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2019.01.032"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13339"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.18176\/jiaci.0384"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2019.01.028"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijp.IJP_39_17"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcod.13659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13659","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13659","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13659","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T11:17:39Z","timestamp":1693653459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13659"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cod.13659"],"URL":"https:\/\/doi.org\/10.1111\/cod.13659","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"type":"print","value":"0105-1873"},{"type":"electronic","value":"1600-0536"}],"subject":[],"published":{"date-parts":[[2020,8,18]]},"assertion":[{"value":"2020-04-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}