{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T12:58:43Z","timestamp":1774270723517,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T00:00:00Z","timestamp":1597708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Notwithstanding that concomitant exposure to different isothiazolinone derivatives may result in concomitant sensitization, clinical and animal studies have suggested cross\u2010reactivity between these derivatives, notably between methylisothiazolinone (MI) and octylisothiazolinone (OIT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate if patients sensitized to MI show cross\u2010reactions to OIT and\/or to benzisothiazolinone (BIT) by applying the concept of the re\u2010test method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients And Methods<\/jats:title><jats:p>From March to October 2019 consecutive patients were patch tested with MI 0.2% aqueous in duplicate at the two lower corners of both shoulder blades. Patients sensitized to MI, but not to OIT 0.1% petrolatum (pet.) nor to BIT 0.1% pet., were re\u2010tested, 2\u2009months later, with the latter two derivatives at the skin sites where the MI reactions had fully disappeared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 116 patients, 15 (13%) were sensitized to MI, eight of these not sensitized to BIT nor to OIT. Of these, seven patients, all (very) strongly sensitized to MI, were re\u2010tested: five patients showed positive patch test reactions to OIT 0.1% pet.; one patient to OIT 0.1% pet. and BIT 0.1% pet.; and one other patient showed no reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that patients primarily and strongly sensitized to MI may show immunologic cross\u2010reactions to OIT, and to a far lesser extent to BIT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13661","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:56:44Z","timestamp":1594799804000},"page":"391-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["In vivo demonstration of immunologic cross\u2010reactivity to octylisothiazolinone in patients primarily and strongly sensitized to methylisothiazolinone"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-384X","authenticated-orcid":false,"given":"Juan Pedro","family":"Russo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Interzonal General de Agudos San Martin de La Plata  10 1121 La Plata Buenos Aires 1900 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA) and University of Antwerp, Research Group Immunology, Infla\u2010Med Centre of Excellence  Antwerp Belgium"},{"name":"Research Group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp 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