{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:40:12Z","timestamp":1787244012709,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n While\n Staphylococcus aureus (S. aureus)<\/jats:italic>\n colonization has been thoroughly studied in atopic dermatitis (AD), where\n S. aureus<\/jats:italic>\n is related to flares and considered a trigger factor,\n S. aureus<\/jats:italic>\n colonization in hand eczema (HE) has only been sparsely studied.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n To examine the 1\u2010week prevalence of\n S. aureus<\/jats:italic>\n colonization in HE patients, and its association with severity, HE subtype, AD, and nasal\n S. aureus<\/jats:italic>\n colonization compared with healthy controls.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In a case\u2010control study of 50 adult HE patients and 50 healthy controls, bacterial swabs from lesional skin (patients only), non\u2010lesional skin (dorsal hand), and the nasal cavity were sampled for culturing of\n S. aureus<\/jats:italic>\n on days 1, 3, 5 and 8. Participants were characterized by demographics, AD, HE subtype, filaggrin gene mutation status, and HE severity.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Twenty\u2010seven HE patients (54%) were colonized with\n S. aureus<\/jats:italic>\n on the hand compared to one control (2%) (\n P<\/jats:italic>\n <\u2009.01). Nasal\n S. aureus<\/jats:italic>\n colonization was found in 72% of patients and 22% of controls (\n P<\/jats:italic>\n <\u2009.01). For patients,\n S. aureus<\/jats:italic>\n colonization on the hands was associated with an atopic HE subtype and HE severity (\n P<\/jats:italic>\n =\u2009.01 and\n P<\/jats:italic>\n <\u2009.01, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Both hand and nasal\n S. aureus<\/jats:italic>\n colonization were highly prevalent among HE\u2010patients and may have an impact on the persistence of HE.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cod.13679","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:50:59Z","timestamp":1595897459000},"page":"442-449","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Colonization with\n \n Staphylococcus aureus<\/i>\n <\/scp>\n in patients with hand eczema: Prevalence and association with severity, atopic dermatitis, subtype and nasal colonization"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3702-1409","authenticated-orcid":false,"given":"Line B.","family":"N\u00f8rreslet","sequence":"first","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie M.","family":"Edslev","sequence":"additional","affiliation":[{"name":"Department of Bacteria, Parasites, and Fungi Statens Serum Institute Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paal S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Bacteria, Parasites, and Fungi Statens Serum Institute Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Plum","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jette","family":"Holt","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention Statens Serum Institute Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Kjerulf","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Epidemiology and Prevention Statens Serum Institute Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E.","family":"Ebbeh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg Hospital, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maja\u2010Lisa","family":"Clausen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esben M.","family":"Flachs","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Bispebjerg Hospital, University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bispebjerg Hospital University of Copenhagen Copenhagen 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