{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T08:27:07Z","timestamp":1771230427634,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In Germany, a multistep approach has been established to prevent work\u2010related skin diseases (WRSDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the effect of a secondary individual prevention program (SIP) in metalworkers with WRSD and to compare their characteristics with those of participants of a tertiary individual prevention program (TIP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>In a prospective cohort study, metalworkers with WRSD of the hands participating either in the SIP (n = 114) or in the TIP (n = 83) were recruited. At baseline and at the respective follow\u2010up 8\u201312\u2009weeks after the SIP or at dismissal from the TIP (3\u20134\u2009weeks later), questionnaires were completed and the severity of WRSD was assessed. Saliva samples were collected for assessment of filaggrin (<jats:italic>FLG<\/jats:italic>) mutations and an explorative genome\u2010wide association study (GWAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ninety\u2010three SIP patients (81.6%) attended the follow\u2010up. Disease severity was significantly reduced, and knowledge and protective behavior were significantly improved compared to baseline. Significant differences between SIP and TIP patients were found regarding duration and severity of symptoms, work absenteeism, tobacco smoking, and presence of atopic dermatitis, but not regarding <jats:italic>FLG<\/jats:italic> mutations and by GWAS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The SIP was effective in metalworkers with WRSDs. Individual factors may influence the course of the disease and the need for the TIP.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13682","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T04:53:31Z","timestamp":1596430411000},"page":"497-506","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of secondary prevention in metalworkers with work\u2010related skin diseases and comparison with participants of a tertiary prevention program: A prospective cohort study"],"prefix":"10.1111","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-024X","authenticated-orcid":false,"given":"Richard","family":"Brans","sequence":"first","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-0449","authenticated-orcid":false,"given":"Annika","family":"Wilke","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Allergology and Venereology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Boraczynski","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Allergology and Venereology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Weidinger","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Allergology and Venereology University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Reich","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-8948","authenticated-orcid":false,"given":"Johannes","family":"Geier","sequence":"additional","affiliation":[{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Allergology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5670-8396","authenticated-orcid":false,"given":"Christoph","family":"Skudlik","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swen M.","family":"John","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Environmental Medicine and Health Theory University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Lower Saxony Institute of Occupational Dermatology University of Osnabr\u00fcck  Osnabr\u00fcck Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2012.07890_suppl.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-008-0300-x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-009-0480-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01976.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02132.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-018-0080-2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01505.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06419.x"},{"issue":"2","key":"e_1_2_8_10_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1610-0387.2008.06864.x","article-title":"Multicenter 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