{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:28Z","timestamp":1790520388414,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Lanolin is often included when patch testing for common contact allergens. The clinical relevance of a positive patch test reaction to lanolin markers is, however, still a subject for debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate Amerchol L101 as a marker of lanolin allergy and investigate the clinical impact of lanolin\u2010containing moisturizers on healthy and damaged skin using the repeated open application test (ROAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twelve test subjects and 14 controls were patch tested with Amerchol L 101 and additional lanolin markers. Subsequently, a blinded ROAT was performed on the arms of the study participants for 4\u2009weeks. Each participant applied a lanolin\u2010free cream base and two different lanolin\u2010containing test creams twice daily on one arm with intact skin and on the other arm with irritant dermatitis, induced by sodium lauryl sulfate (SLS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven test subjects (92%) had positive patch test reactions to Amerchol L 101 when retested and one test subject (8%) had a doubtful reaction. None of the study participants had any skin reactions to the ROAT on intact skin and all participants healed during the ROAT on damaged skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lanolin\u2010containing emollients do not cause or worsen existing dermatitis when performing ROAT in volunteers patch test positive to Amerchol L101.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13689","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T13:49:03Z","timestamp":1598449743000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical relevance of positive patch test reactions to lanolin: A<scp>ROAT<\/scp>study"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3903-151X","authenticated-orcid":false,"given":"Ada","family":"Uldahl","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 Sweden"},{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin","family":"Engfeldt","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 Sweden"},{"name":"Current Address: Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Dermatology Sk\u00e5ne University Hospital, Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1510","article-title":"Zum Kapitel der Hautkrankheiten auf \u201cnerv\u00f6ser\u201d Basis","volume":"69","author":"Marcus A","year":"1922","journal-title":"M\u00fcnch Med Wochenschr"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2008.07060"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1983.tb04448.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1979.tb04801.x"},{"key":"e_1_2_7_6_1","first-page":"99","article-title":"Allergens in lanolin: parts I and II","volume":"34","author":"Takano S","year":"1983","journal-title":"J Soc Cosmet Chem"},{"key":"e_1_2_7_7_1","first-page":"127","article-title":"Skin reactions to ointment bases. 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