{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:28Z","timestamp":1790520388342,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T00:00:00Z","timestamp":1603238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005722","name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","doi-asserted-by":"publisher","award":["F\u00d6FoLe 1022"],"award-info":[{"award-number":["F\u00d6FoLe 1022"]}],"id":[{"id":"10.13039\/501100005722","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The diagnosis of allergic contact dermatitis should be confirmed by skin patch tests. Distinguishing between irritant and allergic reactions is sometimes difficult.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyse the in vivo morphological changes in patch test reactions compared to healthy skin, and to detect subclinical changes in doubtful reactions using optical coherence tomography (OCT). To develop an OCT\u2010based algorithm to support patch\u2010test grading.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>One hundred twenty\u2010nine skin patch\u2010test areas were scanned with OCT to evaluate the following features: architectural and vascular morphology, epidermal thickness, optical attenuation coefficient (AC), and blood flow at 0.1, 0.2, and 0.35\u2009mm depth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most common OCT features of acute contact allergic reactions in patch tests were spongiosis with microvesicles (94.8%), macrovesicles (60.3%), and coalescing vesicles (46.6%), the latter useful in differentiating acute allergic from irritant dermatitis (\n                      <jats:italic>P\u2010<\/jats:italic>\n                      value &lt; .05). Objective quantitative parameters correlated well with the severity grade: epidermal thickness due to spongiosis, AC (\n                      <jats:italic>P\u2010<\/jats:italic>\n                      value &lt; .05) and blood flow at 0.2 and 0.35\u2009mm (\n                      <jats:italic>P\u2010<\/jats:italic>\n                      value &lt; .01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>OCT as a noninvasive diagnostic tool, established for skin cancer diagnosis, is useful for evaluating contact allergic patch\u2010test reactions. Not only morphological but also objective features such as blood flow and AC correlate with the reaction severity. Further studies are needed to explore the differences in irritant and allergic contact dermatitis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.13714","type":"journal-article","created":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T03:11:41Z","timestamp":1601781101000},"page":"183-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Optical coherence tomography for patch test grading: A prospective study on its use for noninvasive diagnosis of allergic contact dermatitis"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9860-1095","authenticated-orcid":false,"given":"Cristel","family":"Ruini","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"},{"name":"Department of Dermatology and PhD Program in Clinical and Experimental Medicine University of Modena and Reggio Emilia  Modena, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Rahimi","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno","family":"Fiocco","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars E.","family":"French","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"},{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami, Miller School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8412-2667","authenticated-orcid":false,"given":"Eva","family":"Oppel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elke","family":"Sattler","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy University Hospital, Ludwig Maximilian University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13119"},{"key":"e_1_2_9_3_1","volume-title":"Weedon's Skin Pathology Essentials","author":"Weedon D","year":"2012"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-019-04528-8"},{"issue":"3","key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S0889-8561(22)00235-1","article-title":"The positive predictive value of patch tests in the evaluation of patients with suspected contact\u2010dermatitis","volume":"9","author":"Nethercott J","year":"1989","journal-title":"Immunol Allergy Clin North Am"},{"issue":"7","key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/ddg.12371","article-title":"Current trends in patch testing \u2010 new data from the German Contact Dermatitis Research Group (DKG) and the Information Network of Departments of Dermatology (IVDK)","volume":"12","author":"Mahler V","year":"2014","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.13956"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8715-y"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15239"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00531.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.2141933"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-015-1714-9"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12695"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15536"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-003-0390-y"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17389"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13367"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14508"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16154"},{"issue":"11","key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1111\/ddg.13971","article-title":"S3 guidelines: epicutaneous patch testing with contact allergens and drugs \u2010 short version, part 2","volume":"17","author":"Mahler V","year":"2019","journal-title":"J Dtsch Dermatol Ges"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.12.001"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029907"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(03)00009-7"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-014-1492-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13563"},{"key":"e_1_2_9_26_1","volume-title":"Textbook of Contact Dermatitis","author":"Rycroft RJ","year":"2013"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbio.201800391"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.24.9.090901"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13714","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13714","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13714","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T07:17:25Z","timestamp":1693639045000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,21]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/cod.13714"],"URL":"https:\/\/doi.org\/10.1111\/cod.13714","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,21]]},"assertion":[{"value":"2020-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}