{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T13:49:04Z","timestamp":1783950544903,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,4]],"date-time":"2020-11-04T00:00:00Z","timestamp":1604448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In 2005, methylisothiazolinone (MI) was allowed as a stand\u2010alone preservative in cosmetics. This resulted in an epidemic of allergic contact dermatitis to MI, mainly affecting women exposed to leave\u2010on cosmetics. Consequently, a regulation of Annex V in the European Union in 2017 banned the use of MI in leave\u2010on cosmetics and reduced the allowed concentration in rinse\u2010off products.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the temporal trends in contact allergy to MI in Danish patients in relation to key events including European regulations over time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective study of consecutive patients patch tested with methylisothiazolinone from 2005 to 2019. Demographics and clinical characteristics in terms of MOAHLFA (male, occupational, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis and age\u2009&gt;40\u2009years), sources of exposure, and clinical relevance were analyzed in relation to key historical events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred eighty of 12\u2009494 patients (3.0%, 95CI: 2.7\u20133.4%) tested from 2005 to 2019 were sensitized to MI. An increasing trend in the prevalence of MI contact allergy from 2005 to 2019 (<jats:italic>P<\/jats:italic> &lt;\u2009.01) was observed, although a decline in the absolute number of patch\u2010test positive patients was seen from 2013 and onward. A reduction in leave\u2010on cosmetics as a source of exposure was observed following the legislative ban in 2017, from 24.8% from in 2010 to 2013 to 6.2% in 2017 to 2019 (<jats:italic>P<\/jats:italic> &lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The epidemic of MI contact allergy is declining in absolute terms, although the prevalence in the patch\u2010tested population has not returned to its pre\u2010epidemic levels. The legislative regulation of MI in 2017 has been effective in terms of leave\u2010on cosmetics as a source of exposure in MI allergic patients. The process of post\u2010marketing risk assessment of contact allergens in the European Union needs improvement.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13717","type":"journal-article","created":{"date-parts":[[2020,10,12]],"date-time":"2020-10-12T17:53:41Z","timestamp":1602525221000},"page":"254-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The epidemic of contact allergy to methylisothiazolinone\u2014An analysis of <scp>Danish<\/scp> consecutive patients patch tested between 2005 and 2019"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2147-016X","authenticated-orcid":false,"given":"Martin","family":"Havmose","sequence":"first","affiliation":[{"name":"National Allergy Research Center, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"National Allergy Research Center, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Center, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01668.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-68617-2_216"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00850.x"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"201","article-title":"Occupational contact allergy and dermatitis from methylisothiazolinone after contact with wallcovering glue and after a chemical burn from a biocide","volume":"15","author":"Isaksson M","year":"2004","journal-title":"Dermatitis"},{"key":"e_1_2_10_6_1","unstructured":"The Scientic Committee on Cosmetic Products and Non\u2010Food Products Intended for Consumers.Opinion Concerning Methylisothiazolinone (Colipa No. P94). 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