{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T04:31:24Z","timestamp":1770611484361,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T00:00:00Z","timestamp":1604534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>During the first wave of the COVID\u201019 pandemic of Spring 2020, Denmark was one of the first countries to introduce lockdown measures, including closing of all daycare centers. Following the reopening of daycare centers, Danish Health Authorities implemented a mandatory intensive hand hygiene regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine the occurrence and point prevalence of hand eczema as a consequence of more intensive hand hygiene among Danish children attending daycare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The heads of 1667 daycare centers in Denmark were contacted and asked to forward a link to a questionnaire to parents of the children attending the daycare center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 6858 children, 12.1% had hand eczema before reopening of daycare centers, whereas 38.3% reported hand eczema after the children returned to daycare. Of the children who never had hand eczema, 28.6% developed hand eczema after returning to daycare. The risk of hand eczema was significantly associated with atopic dermatitis, female gender, higher age, and frequency of handwashing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Following the implemented hygiene regimen, a high proportion of young children rapidly developed hand eczema. Well\u2010established prophylactic skin care might have spared a proportion of the children from developing hand eczema.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13727","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T11:01:53Z","timestamp":1603278113000},"page":"144-152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Increased occurrence of hand eczema in young children following the <scp>Danish<\/scp> hand hygiene recommendations during the <scp>COVID<\/scp>\u201019 pandemic"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-0317","authenticated-orcid":false,"given":"Anne B.","family":"Simonsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-360X","authenticated-orcid":false,"given":"Iben F.","family":"Ruge","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-4545","authenticated-orcid":false,"given":"Anna S.","family":"Quaade","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Zachariae","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital, Herlev and Gentofte  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09099.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07185.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-03827-3_3"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16061"},{"key":"e_1_2_10_6_1","unstructured":"Guidelines for Reopening of Daycare Centers and Schools 2020.https:\/\/www.skolelederforeningen.org\/nyheder-medier\/nyheder\/2020\/genaabning-saa-kom-sundhedsstyrelsens-vejledninger-ifm-aabning-af-skoler-mm\/. 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