{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T02:07:49Z","timestamp":1788746869754,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Polyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad\u2010spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed, we have included PHMB as a screening allergen since 2016.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the prevalence of positive patch test reactions to PHMB as a screening allergen in patients with suspected allergic contact dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 1760 patch tested patients from July 2016 to December 2018 was performed. Polyaminopropyl biguanide 2.0% aqua was included in the extended Malm\u00f6 baseline series during the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of all patients, 1204 (68.4%) were female. Positive patch test reactions were reported in 19 patients (1.1%). The most common sites of lesions were face, head, and neck (52.6%). There was a significant correlation between concomitant reactions to PHMB and other cosmetic\u2010related allergens.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of positive reactions to PHMB was higher than that previously reported. Patch testing with PHMB should be performed in patients with dermatitis who have lesions on the face, head, and neck.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13728","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T07:41:31Z","timestamp":1603525291000},"page":"326-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide)"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-2988","authenticated-orcid":false,"given":"Thanisorn","family":"Sukakul","sequence":"first","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"},{"name":"Department of Dermatology, Faculty of Medicine Siriraj Hospital Mahidol University Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Dahlin","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Pont\u00e9n","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5067-2564","authenticated-orcid":false,"given":"Annarita","family":"Antelmi","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2919-3227","authenticated-orcid":false,"given":"Magnus","family":"Bruze","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5188-7711","authenticated-orcid":false,"given":"Nils","family":"Hamnerius","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inese","family":"Hauksson","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9005-0962","authenticated-orcid":false,"given":"Marl\u00e9ne","family":"Isaksson","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9116-8268","authenticated-orcid":false,"given":"Tina","family":"Lejding","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Svedman","sequence":"additional","affiliation":[{"name":"Lund University Department of Occupational and Environmental Dermatology, Sk\u00e5ne University Hospital Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12]]},"reference":[{"key":"e_1_2_8_2_1","volume-title":"International Cosmetic Ingredient Dictionary and Handbook","author":"Nikitakis J","year":"2016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000294"},{"key":"e_1_2_8_4_1","unstructured":"Scientific Committee on Consumer Safety.Opinion on Polyaminopropyl Biguanide (PHMB) \u2010 Submission III. 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