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In doubtful reactions to FM I\/II with negative breakdown testing, NMF was significantly lower than in petrolatum controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PT reactions to thiurams and fragrances indicate a Th2\u2010skewed inflammation. The inflammatory profiles suggest that weak or doubtful FM I\/II reactions without accompanying reaction to a constituent were irritant. IL\u201016 might be suitable to distinguish irritant from allergic reaction.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13746","type":"journal-article","created":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T06:26:04Z","timestamp":1606026364000},"page":"299-307","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>Stratum corneum<\/i> levels of inflammatory mediators and natural moisturizing factor in patch test reactions to thiurams and fragrances and their possible role in discrimination between irritant and allergic reactions to hapten mixtures"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1245-024X","authenticated-orcid":false,"given":"Richard","family":"Brans","sequence":"first","affiliation":[{"name":"Institute for Interdisciplinary Dermatologic Prevention and Rehabilitation (iDerm) at the University of Osnabr\u00fcck  Osnabr\u00fcck Germany"},{"name":"Department 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