{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:03:55Z","timestamp":1773270235918,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,2,28]],"date-time":"2021-02-28T00:00:00Z","timestamp":1614470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fragrances constitute the second most frequent cause of allergic contact dermatitis in Spain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the rate of sensitization to the individual fragrances of fragrance mix (FM) I and FM II for each of the demographic and clinical factors included in the MOAHLFA (male, occupational dermatitis, atopic dermatitis, hand dermatitis, leg dermatitis, facial dermatitis, age) index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a 5\u2010year retrospective study in 23 Spanish centres. We identified the patients who had undergone patch testing with a specific fragrance series after reacting positively to fragrance markers in a baseline series. We obtained the MOAHLFA index items in this population, then calculated for each demographic and clinical factor the frequencies of sensitization to the individual fragrances of FM I and FM II.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A specific fragrance series was patch tested in 1013 patients. The most frequent allergens in men, women, children, and retired people were <jats:italic>Evernia prunastri<\/jats:italic> (16%), geraniol (16.6%), isoeugenol (17.9%), and geraniol (22.4%), respectively. Citral (20.5%) and hydroxyisohexyl 3\u2010cyclohexene carboxaldehyde (HICC) (14.5%) were the most common allergens in occupational eczemas and were also associated with a large proportion of hand and facial dermatitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Frequency of sensitization to the individual fragrances of FM I and FM II varies with age, sex, affected body region, and history of occupational or atopic dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13801","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T14:05:22Z","timestamp":1612620322000},"page":"395-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Frequency of sensitization to the individual fragrances of fragrance mix <scp>I<\/scp> and <scp>II<\/scp> according to the factors included in the <scp>MOAHLFA<\/scp> index"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1418-9161","authenticated-orcid":false,"given":"Mar\u00eda J.","family":"S\u00e1nchez\u2010Pujol","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante\u2010ISABIAL  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Docampo\u2010Sim\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Alicante\u2010ISABIAL  Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-9725","authenticated-orcid":false,"given":"Pedro","family":"Mercader","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Jose M Morales Meseguer  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Gonz\u00e1lez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba  Vitoria Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Hervella\u2010Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Navarra  Pamplona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-7680","authenticated-orcid":false,"given":"Tatiana","family":"Sanz\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Infanta Sofia  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"C\u00f3rdoba","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Fuenlabrada Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"S\u00e1nchez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de la Princesa  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe","family":"Heras\u2010Mendaza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fundaci\u00f3n Jim\u00e9nez\u2010D\u00edaz  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana M.","family":"Gim\u00e9nez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar, Universitat Aut\u00f2noma Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5834","authenticated-orcid":false,"given":"Mar\u00eda E.","family":"Gatica\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-5419","authenticated-orcid":false,"given":"Mar\u00eda A.","family":"Pastor\u2010Nieto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Guadalajara  Guadalajara Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Violeta","family":"Zaragoza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Consorci Hospital Universitari de Valencia  Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M.","family":"Carrascosa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Germans Trias i Pujol  Badalona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bego\u00f1a","family":"Garc\u00eda\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de la Macarena  Sevilla Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inmaculada","family":"Ruiz\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Le\u00f3n  Le\u00f3n Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2756","authenticated-orcid":false,"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hospital Universitario Insular de Gran Canaria Universidad de Las Palmas de Gran Canaria  Las Palmas Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paloma","family":"S\u00e1nchez\u2010Pedre\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Virgen de la Arrixaca  Murcia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier O.","family":"de Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario 12 de Octubre  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 C.","family":"Armario\u2010Hita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Puerto Real  C\u00e1diz Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Garc\u00eda\u2010Gav\u00edn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario de Vigo  Vigo 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