{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:26:04Z","timestamp":1770488764026,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In about half of the patients reacting positive to fragrance mix I (FM I), breakdown testing remains negative. This raises the question of whether the reaction to FM I is false\u2010positive, or the breakdown test is false\u2010negative.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To identify characteristics and sensitization patterns of patients positive to FM I, but not to its fragrance constituents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>Retrospective analysis of data from the Information Network of Departments of Dermatology (IVDK) between 2005 and 2019. Three patient groups were defined according to their reaction pattern: Group I, FM I positive and \u22651 single fragrance positive in the breakdown test (n = 1912); Group II, FM I positive and breakdown test negative (n = 1318); Group III, FM I negative (n = 19\u2009790).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Regarding the pattern of concomitant reactions to other fragrances, Group II had an intermediate position between Group I and Group III. In other respects (age and sex distribution, frequency of sensitization to non\u2010fragrance baseline series allergens), Group II rather resembled Group I.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Not every positive reaction to FM I in patients with negative breakdown tests is false\u2010positive. There may be false\u2010negative reactions to the single fragrance components when patch tested at 1% pet. Raising patch concentrations of some single fragrances is recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13803","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T13:00:30Z","timestamp":1612616430000},"page":"407-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A negative breakdown test in a fragrance mix I\u2010positive patient does not rule out contact allergy to its fragrance constituents"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5047-8948","authenticated-orcid":false,"given":"Johannes","family":"Geier","sequence":"first","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2359-2518","authenticated-orcid":false,"given":"Steffen","family":"Schubert","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5725-7734","authenticated-orcid":false,"given":"Axel","family":"Schnuch","sequence":"additional","affiliation":[{"name":"Information Network of Departments of Dermatology (IVDK) Institute at the University Medical Center G\u00f6ttingen  G\u00f6ttingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Szliska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bethesda Hospital  Freudenberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elke","family":"Weisshaar","sequence":"additional","affiliation":[{"name":"Occupational Dermatology, Department of Dermatology Ruprecht\u2010Karl University Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birger","family":"Kr\u00e4nke","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz  Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Werfel","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Division of Immunodermatology and Allergy Research Hannover Medical School  Hannover Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franziska","family":"Ru\u00ebff","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology Ludwig\u2010Maximilian University of Munich  Munich 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