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The aim of this systematic review and meta\u2010analysis was to provide updated estimates of prevalence and incidence, alongside additional epidemiological endpoints on HE in the general population. PubMed, Embase and Web of Science were searched for studies reporting the prevalence and\/or incidence of HE in the general population. Proportion meta\u2010analyses were performed to calculate pooled estimates of prevalence, incidence, severity, and the proportion of individuals with HE and a history of atopic dermatitis. Sixty\u2010six studies were included in the quantitative analysis encompassing 568\u2009100 individuals. The pooled estimates for lifetime, 1\u2010year, and point prevalence were 14.5% (95% confidence interval [CI]: 12.6\u201316.5), 9.1% (95% CI: 8.4\u20139.8) and 4.0% (95% CI: 2.6\u20135.7), respectively. The pooled incidence rate of HE was 7.3 cases\/1000 person\u2010years (95% CI: 5.4\u20139.5). The occurrence of HE was 1.5\u20132 times higher in females than males. More than one third suffered from moderate\/severe disease and around one third had a history of atopic dermatitis. HE was a recurrent, long\u2010lasting disease with an average age at onset of the early\u2010 to mid\u2010twenties. In conclusion; HE is a highly prevalent disease in the general population and carries a significant risk of long\u2010term or chronic disease.<\/jats:p>","DOI":"10.1111\/cod.13804","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T11:14:46Z","timestamp":1612610086000},"page":"361-374","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":165,"title":["Prevalence, incidence, and severity of hand eczema in the general population \u2013 A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8966-4545","authenticated-orcid":false,"given":"Anna S.","family":"Quaade","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-0317","authenticated-orcid":false,"given":"Anne B.","family":"Simonsen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0166-6560","authenticated-orcid":false,"given":"Anne\u2010Sofie","family":"Halling","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"},{"name":"Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy, Herlev and Gentofte Hospital University of Copenhagen  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16061"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13113"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2003.00159.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.045002099.x"},{"key":"e_1_2_9_7_1","unstructured":"WellsG SheaB O'ConnellD et al.The Newcastle\u2013Ottawa Scale (NOS) for Assessing the Quality of Non\u2010Randomized Studies in Meta\u2010Analysis. 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