{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:04:48Z","timestamp":1773965088720,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>How changes in hand eczema (HE) severity correlate with the single scores on the Hand Eczema Severity Index (HECSI) is sparsely investigated and particularly needed in clinical trials.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To find the minimal important change (MIC) for HECSI based on patient's and physician's assessments using different methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective follow\u2010up study, three different anchors were used: two anchor questions for patients and physician, respectively, and the Physician Global Assessment (PGA) with a photographic guide. MIC was estimated by mean change in patients with a one\u2010step increase to anchor\u2010questions, receiver\u2010operating characteristic (ROC) plot, and smallest detectable change (SDC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred fifty\u2010two patients with HE (63.8% female) were included at baseline (89% completed follow\u2010up). The mean change, ROC cutoff, and SDC values were 7.1, 4.5, 21.4 (patient\u2010rating), 8.2, 4.5, 8.3 (physician\u2010rating), and 16.6, 6.5, 27.1 points (PGA), respectively. SDC stratified by baseline severity was 2.9 and 11 points for mild and moderate\u2010severe HE (physician\u2010rating), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identification of the MIC for the HECSI is important in relation to evaluation of treatment, intervention, and sample\u2010size calculations. An improvement of 8.3 points on the HECSI is recommended as the MIC. MIC values may differ according to baseline severity, and this variation should be clarified in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13828","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T16:04:32Z","timestamp":1614787472000},"page":"164-170","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["New evidence on the minimal important change (MIC) for the Hand Eczema Severity Index (HECSI)"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-1827","authenticated-orcid":false,"given":"Yasemin Topal","family":"Y\u00fcksel","sequence":"first","affiliation":[{"name":"Department of Dermatology Bispebjerg &amp; Frederiksberg Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-8299","authenticated-orcid":false,"given":"Tove","family":"Agner","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bispebjerg &amp; Frederiksberg Hospital, University of Copenhagen  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-6110","authenticated-orcid":false,"given":"Robert","family":"Ofenloch","sequence":"additional","affiliation":[{"name":"Occupational Dermatology, Department of Dermatology University Hospital Heidelberg  Heidelberg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01669.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.16062"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18469"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14982"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2521"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2006.00871.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08870.x"},{"key":"e_1_2_9_9_1","first-page":"133","article-title":"Diagnostics in the investigation of occupational skin diseases \u2013 I: operationalisation of the clinical findings (Manuscore)","author":"John SM","year":"2001","journal-title":"Clin Exp Stud Diagnostics Occup Dermatology Osnabr\u00fcck Univ Rasch"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06305.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09463.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13212"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18295"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"212","article-title":"Prevention of hand eczema: effect of an educational program versus treatment as usual \u2013 results of the randomized clinical PREVEX trial","volume":"44","author":"Fisker MH","year":"2018","journal-title":"Scand J Work Environ Health"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12964"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e7822"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/0022-006X.59.1.12"},{"key":"e_1_2_9_19_1","unstructured":"Menn\u00e9T VeienN SommerlundM Johansen J.H\u00e5ndeksem.Operationelle retningslinier for udredning og behandling.Dansk Kontakt Dermatitis Gruppe; 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