{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T21:33:41Z","timestamp":1784064821440,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The preservatives sorbic acid (SA) and potassium sorbate (PS) are considered rare skin sensitizers. PS\u2010containing products always contain SA to a certain extent, and positivity to PS may reflect sensitization to SA. Their optimal patch test conditions are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report on the outcome of testing with SA and PS in various concentrations and\/or vehicles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Seventeen patients with allergic contact dermatitis from PS\/SA\u2010containing topical pharmaceuticals and medical devices were patch tested to SA 2% and 5% pet.; SA 1%, 2%, 3%, 5%. eth.; and\/or SA 2% aq., whereas PS was patch tested 5% pet. and\/or 5% aq.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only one patient, not tested to the ethanol preparations, presented with a (doubtful) positive reaction to SA 2% pet., while this remained negative in 13 patients who reacted to SA 2% eth. The preparations containing SA 5% pet.; 1%, 3%, and 5% eth.; and SA 2% aq. had little or no additional value. PS 5% pet. performed better than 5% aq., and always mirrored SA sensitization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sensitization to SA and PS is probably underestimated. SA 2% eth. and PS 5% pet. are preferred for patch testing, and patients sensitized to SA should avoid PS\u2010containing products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13829","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T15:49:14Z","timestamp":1614786554000},"page":"171-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Allergic contact dermatitis from potassium sorbate and sorbic acid in topical pharmaceuticals and medical devices"],"prefix":"10.1111","volume":"85","author":[{"given":"Ella","family":"Dendooven","sequence":"first","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Antwerp Belgium"},{"name":"Research group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"},{"name":"Research group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kerre","sequence":"additional","affiliation":[{"name":"Department of Dermatology Imelda Hospital  Bonheiden Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[{"name":"Research group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[{"name":"Research group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Antwerp Belgium"},{"name":"Research group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Antwerp Belgium"},{"name":"Research group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-72451-5_85-2"},{"key":"e_1_2_10_3_1","unstructured":"Eastman. 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