{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:46:18Z","timestamp":1790520378696,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006286","name":"Kongelig Hofbuntmager Aage Bangs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007036","name":"Milj\u00f8styrelsen","doi-asserted-by":"publisher","award":["A grant to the National Allergy Research Centre"],"award-info":[{"award-number":["A grant to the National Allergy Research Centre"]}],"id":[{"id":"10.13039\/501100007036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Exposure to nickel releasing ear piercing jewellery may explain the persistently high prevalence of nickel allergy in Europe. While nickel release from earrings is regulated, field studies show that the regulation is not always respected. More knowledge is needed regarding the risk of piercing exposure including suitable screening methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the proportion of earrings on the Danish market that release more nickel than allowed, and to validate the use of the dimethylglyoxime (DMG) test as a screening tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 304 earrings were purchased and tested with the DMG test and X\u2010ray fluorescence spectrometry. The level of nickel release was quantified in a selected subsample of 100 earrings by the European reference test EN 1811. The DMG spot test was validated against EN 1811 at different thresholds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Excessive nickel release according to the European regulation was found in 45 (14.8%) tested earrings. The sensitivity of the DMG test decreased with reduced levels of nickel release (sensitivity of 45.2% at \u22650.2\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>\/week vs 61.1% at &gt;0.5\u2009\u03bcg\/cm<jats:sup>2<\/jats:sup>\/week).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Excessive nickel release is common in earrings on the Danish market. Because of low sensitivity, the DMG test has limited use in screening of earrings for research but may still be used clinically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13832","type":"journal-article","created":{"date-parts":[[2021,3,13]],"date-time":"2021-03-13T17:27:10Z","timestamp":1615656430000},"page":"178-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Nickel release from metallic earrings: A survey of the Danish market and validation of the nickel spot test"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-283X","authenticated-orcid":false,"given":"Michael","family":"Wennervaldt","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2092-7826","authenticated-orcid":false,"given":"Malin G.","family":"Ahlstr\u00f6m","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torkil","family":"Menn\u00e9","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3770-1743","authenticated-orcid":false,"given":"Jacob P.","family":"Thyssen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne D.","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Copenhagen University Hospital Herlev\u2010Gentofte  Hellerup Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12846"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13327"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13394"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14167"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04307.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000066"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/000155502320624096"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12782"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000324"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00523.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12775"},{"key":"e_1_2_10_13_1","first-page":"1","article-title":"Regulation (EC) No 1907\/2006 of the European Parliament and of the council of 18 December 2006 concerning the registration, evaluation, authorisation and restriction of chemicals (REACH)","volume":"396","author":"The Commission of the European Communities","year":"2006","journal-title":"Off J Eur Union"},{"issue":"164","key":"e_1_2_10_14_1","first-page":"7","article-title":"Commission regulation (EC) no 552\/2009 amending regulation (EC) no 1907\/2006 of the European Parliament and of the council on the registration, evaluation, authorisation and restriction of chemicals (REACH) as regards annex XVII","volume":"52","author":"The Commission of the European Communities","year":"2009","journal-title":"Off J Eur Union"},{"key":"e_1_2_10_15_1","unstructured":"European Committee for Standardization (CEN).Reference Test Method for Release of Nickel from all Post Assemblies which Are Inserted into Pierced Parts of the Human Body and Articles Intended to Come into Direct and Prolonged Contact with the Skin. 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