{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:37:30Z","timestamp":1790879850578,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Methyldibromo glutaronitrile (MDBGN) was one of the most frequent and relevant allergens found in patch testing at the beginning of this century. In 2008, this preservative was banned from cosmetics in Europe and ever since the prevalence of contact allergy to MDBGN has progressively decreased. Despite that gradual decline, MDBGN is still patch\u2010tested in most baseline series. This study assessed the frequency of MDBGN sensitization, epidemiological characteristics of allergic patients, and the relevance of positive patch tests in a nationwide Spanish registry (REIDAC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>We evaluated consecutively patch\u2010tested patients in all participating centres. Using these data, we calculated the proportion of patients with positive patch tests to MDBGN from June 2018 to June 2020 and evaluated the relevance of the positive patch tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred and fourteen out of 5072 (2.24 %) tested patients were sensitized to MDBGN. Clinical current relevance was confirmed in only one case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the frequency of contact allergy to MDBGN remains high, no clinical significance was found in most of these patients (5072 tests needed to obtain one relevant positive result). The clinical usefulness of this allergen seems weak and its continued inclusion in the European baseline series is questionable.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.13837","type":"journal-article","created":{"date-parts":[[2021,3,21]],"date-time":"2021-03-21T09:41:10Z","timestamp":1616319670000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Should methyldibromo glutaronitrile continue to be used in the European baseline Series? A <scp>REIDAC<\/scp> national cross\u2010sectional study"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8309-9725","authenticated-orcid":false,"given":"Pedro","family":"Mercader\u2010Garc\u00eda","sequence":"first","affiliation":[{"name":"Deparment of Dermatology Hospital General Universitario Jose M\u00aa Morales Meseguer  Murcia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8382-5419","authenticated-orcid":false,"given":"Mar\u00eda Antonia","family":"Pastor\u2010Nieto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario de Guadalajara  Guadalajara Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-215X","authenticated-orcid":false,"given":"Ricardo","family":"Gonzalez\u2010Perez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario Araba  Vitoria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1809-4821","authenticated-orcid":false,"given":"Susana","family":"Cordoba\u2010Guijarro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario de Fuenlabrada  Fuenlabrada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5434-7753","authenticated-orcid":false,"given":"Ana Mar\u00eda","family":"Gimenez\u2010Arnau","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar. IMAS  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5101-466X","authenticated-orcid":false,"given":"Inmaculada","family":"Ruiz\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Asistencial Universitario de Le\u00f3n  Leon Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0016-9781","authenticated-orcid":false,"given":"Ver\u00f3nica","family":"Mora\u2010Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitari German Trias i Pujol  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Miquel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Arnau de Vilanova  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8532-6338","authenticated-orcid":false,"given":"Juan Francisco","family":"Silvestre\u2010Salvador","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario  Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0635-0971","authenticated-orcid":false,"given":"Francisco Javier","family":"Ortiz\u2010Frutos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario 12 de octubre  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-7680","authenticated-orcid":false,"given":"Tatiana","family":"Sanz\u2010Sanchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario Infanta Sofia  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2690-3668","authenticated-orcid":false,"given":"Mercedes","family":"Rodriguez\u2010Serna","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital General Universitario La Fe  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3906-5026","authenticated-orcid":false,"given":"Patricia","family":"Perez\u2010Feal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario Santiago de Compostela  Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1240-1015","authenticated-orcid":false,"given":"Javier","family":"S\u00e1nchez\u2010P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitario La Princesa  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5016-173X","authenticated-orcid":false,"given":"Felipe","family":"Heras\u2010Mendaza","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Fundaci\u00f3n Jim\u00e9nez Diaz  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-0300","authenticated-orcid":false,"given":"Ester","family":"Serra\u2010Baldrich","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital de la Santa Creu i Sant Pau  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Violeta","family":"Zaragoza\u2010Ninet","sequence":"additional","affiliation":[{"name":"Department of Dermatology Consorcio Hospital General Universitario de Valencia  Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5238-9562","authenticated-orcid":false,"given":"Marcos","family":"Hervella\u2010Garces","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Navarra  Pamplona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8203-5834","authenticated-orcid":false,"given":"Mar\u00eda Elena","family":"Gatica\u2010Ortega","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario de Toledo  Toledo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6881-5260","authenticated-orcid":false,"given":"Ignacio","family":"Garc\u00eda\u2010Doval","sequence":"additional","affiliation":[{"name":"Research Unit Fundaci\u00f3n Piel Sana Academia Espa\u00f1ola de Dermatolog\u00eda y Venereolog\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2262-7547","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Descalzo","sequence":"additional","affiliation":[{"name":"Research Unit Fundaci\u00f3n Piel Sana Academia Espa\u00f1ola de Dermatolog\u00eda y Venereolog\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-2756","authenticated-orcid":false,"given":"Leopoldo","family":"Borrego","sequence":"additional","affiliation":[{"name":"Department of Dermatology Complejo Hospitalario Universitario Insular Materno Infantil. Universidad de las Palmas de Gran Canaria  Las Palmas de Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the REIDAC group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2011.10081"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1989.tb03180.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1991.tb01815.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1992.tb00878.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.460404.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00482.x"},{"key":"e_1_2_9_8_1","unstructured":"EUR\u2010Lex \u2010 32003L0083 \u2010 EN \u2010 EUR\u2010Lex.https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=uriserv%3AOJ.L_.2003.238.01.0023.01.ENG&toc=OJ%3AL%3A2003%3A238%3ATOC. Accessed November 15 2020."},{"key":"e_1_2_9_9_1","unstructured":"EUR\u2010Lex \u2010 32007L0017 \u2010 EN \u2010 EUR\u2010Lex.https:\/\/eur-lex.europa.eu\/eli\/dir\/2007\/17\/oj. Accessed November 15 2020."},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2008.01364.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10253.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12446"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.18975"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14063"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2016.04.009"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_9_17_1","unstructured":"Biocidal Products Committee (BPC).https:\/\/echa.europa.eu\/documents\/10162\/ee68ecaf-7d48-4bb5-9842-3dfbb5d3e7a7. Accessed November 29 2020."},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02091.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12768"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15505"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13155"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13837","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13837","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T08:43:59Z","timestamp":1735807439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":20,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1111\/cod.13837"],"URL":"https:\/\/doi.org\/10.1111\/cod.13837","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"2021-01-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}