{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T06:19:19Z","timestamp":1788589159931,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T00:00:00Z","timestamp":1618272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic ultraviolet filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To verify if, and to what extent, BP residues are present in OCT\u2010containing consumer products.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chemically analysed for the presence of BP by means of liquid chromatography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the OCT raw material and in all 28 OCT\u2010containing products the presence of BP could be demonstrated, mostly in concentrations above 10\u2009ppm (0.001%), whereas a majority of OCT\u2010free products (8\/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time\u2010 and temperature\u2010dependent manner, likely due to the additional degradation of OCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicological and ecological studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.13845","type":"journal-article","created":{"date-parts":[[2021,3,25]],"date-time":"2021-03-25T03:21:41Z","timestamp":1616642501000},"page":"69-77","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["The presence of benzophenone in sunscreens and cosmetics containing the organic\n                    <scp>UV<\/scp>\n                    filter octocrylene: A laboratory study"],"prefix":"10.1111","volume":"85","author":[{"given":"Kenn","family":"Foubert","sequence":"first","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Dendooven","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"},{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Edegem Belgium"},{"name":"Research Group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mart","family":"Theunis","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Naessens","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boryana","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp (UA)  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0927-3104","authenticated-orcid":false,"given":"Liesbeth","family":"Gilissen","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Huygens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-6192","authenticated-orcid":false,"given":"Wim","family":"De Borggraeve","sequence":"additional","affiliation":[{"name":"Department of Chemistry KU Leuven Chem&amp;Tech  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Lambert","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Edegem Belgium"},{"name":"Research Group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospitals KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-2887","authenticated-orcid":false,"given":"Olivier","family":"Aerts","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Hospital Antwerp (UZA)  Edegem Belgium"},{"name":"Research Group Immunology, Infla\u2010Med Centre of Excellence University of Antwerp  Antwerp Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,13]]},"reference":[{"issue":"38","key":"e_1_2_10_2_1","first-page":"6204","article-title":"Sunscreen drug products for over\u2010the\u2010counter human use: proposed rule","volume":"84","author":"US Food and Drug Administration (FDA)","year":"2019","journal-title":"Fed Regist"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.5586"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.20747"},{"key":"e_1_2_10_5_1","unstructured":"ECHA. Octocrilene\u2014Registration Dossier;https:\/\/echa.europa.eu\/nl\/registration-dossier\/-\/registered-dossier\/14858. Accessed March 02 2021."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15945"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12205"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12761"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2010.132"},{"key":"e_1_2_10_10_1","unstructured":"International Agency for Research on Cancer (IARC). 2013. Benzophenone. IARC Monographs on the evaluation of carcinogenic risks humans 101: 285\u2010304.https:\/\/monographs.iarc.fr\/wp-content\/uploads\/2018\/06\/mono101-007.pdf. Accessed December 4 2020."},{"key":"e_1_2_10_11_1","unstructured":"\u5c45\u6c88\u8d35\u859b\u5cf0. Method of preparing Octocrilene. (ed. CN) (China 2009).https:\/\/patents.google.com\/patent\/CN101492394B. 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