{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T02:51:44Z","timestamp":1768445504764,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T00:00:00Z","timestamp":1618704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aluminium contact allergy is mainly seen as granulomas following immunization with aluminium\u2010adsorbed vaccines and contact allergy following epicutaneous exposure may be overlooked. To investigate the prevalence of aluminium allergy confirmed by patch testing, with no association with vaccination granulomas, and explore whether epicutaneous exposure to aluminium can contribute to allergic contact dermatitis. Two authors independently searched PubMed and MEDLINE (OVID) for case studies on contact allergy to aluminium proven by patch testing. Age\u2010stratified meta\u2010analyses to calculate the pooled prevalence were performed. Twenty\u2010five studies describing a total of 73 cases were included in the review. Seven studies were suitable for meta\u2010analyses. The prevalence of aluminium contact allergy was 5.61% (95% confidence interval [CI] 0.12%\u201011.08%) for children and 0.36% (95% CI 0.04%\u20100.67%) for adults. The studies described a variety of epicutaneous exposures, where metallic aluminium, topical medicaments, and deodorants were the main sources. Aluminium sensitization without a known exposure source was described in 10 of the 25 articles. The prevalence of aluminium contact allergy in the general public may be higher than expected and not solely related to vaccination granulomas. However, the clinical relevance is rare if not related to granulomas.<\/jats:p>","DOI":"10.1111\/cod.13852","type":"journal-article","created":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T05:39:37Z","timestamp":1617341977000},"page":"129-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Aluminium contact allergy without vaccination granulomas: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3983-2264","authenticated-orcid":false,"given":"Stine Skovbo","family":"Hoffmann","sequence":"first","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5071-283X","authenticated-orcid":false,"given":"Michael","family":"Wennervaldt","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1527-4242","authenticated-orcid":false,"given":"Farzad","family":"Alinaghi","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9299-0317","authenticated-orcid":false,"given":"Anne Birgitte","family":"Simonsen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"},{"name":"Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3537-8463","authenticated-orcid":false,"given":"Jeanne Duus","family":"Johansen","sequence":"additional","affiliation":[{"name":"National Allergy Research Centre, Department of Dermatology and Allergy Herlev and Gentofte Hospital, University of Copenhagen  Hellerup 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