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By blocking IL\u20101\u03b2 and investigating the IL\u20101\u03b2 signaling pathway, several studies have demonstrated a central role of IL\u20101\u03b2 in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL\u20101\u03b2 in the different phases of allergic contact dermatitis (ACD) and highlights potential IL\u20101\u03b2\u2010targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL\u20101\u03b2 in ACD are lacking.<\/jats:p>","DOI":"10.1111\/cod.13955","type":"journal-article","created":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T16:20:10Z","timestamp":1627575610000},"page":"387-397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The role of interleukin\u2010<scp>1\u03b2<\/scp> in the immune response to contact allergens"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6083-3475","authenticated-orcid":false,"given":"Kelvin","family":"Yeung","sequence":"first","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Mraz","sequence":"additional","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8472-0771","authenticated-orcid":false,"given":"Carsten","family":"Geisler","sequence":"additional","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Skov","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy Copenhagen University Hospital \u2010 Herlev and Gentofte  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-6229","authenticated-orcid":false,"given":"Charlotte M.","family":"Bonefeld","sequence":"additional","affiliation":[{"name":"The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.02.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.180.9.5826"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20092489"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700819"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12270"},{"issue":"5","key":"e_1_2_9_7_1","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.4049\/jimmunol.151.5.2390","article-title":"Inhibition of Langerhans cell antigen\u2010presenting function by IL\u201010. 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