{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:17Z","timestamp":1787014037505,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Preservatives are used widely in cosmetic, household, and industrial products to prevent microbial growth and spoiling of the products. There has been a recent epidemic of contact allergy to methylisothiazolinone (MI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To establish emerging trends in preservative contact allergy as MI is replaced.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We performed a retrospective study on consecutively patch\u2010tested patients at our center from January 2011 to December 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 7846 consecutively patch\u2010tested patients were included who were patch tested between January 2011 and December 2019. The prevalence of allergy to MI fell from a peak of 9.39% in 2013 to 1.98% in 2019. MI\/methylchloroisothiazolinone (MCI) followed a similar trend, with a peak prevalence of 7.85% in 2014 and falling to 1.39% in 2018. The prevalence of contact allergy to benzisothiazolinone (BIT) has increased steadily increased in 2014 from 0.26% (confidence interval [CI] 0.03\u20100.93) to 3.42% (CI 2.43\u20104.66) in 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our data show a significant increase in the prevalence of contact allergy to BIT over the last 6\u2009years, probably as a consequence of increased use in household products. It is essential to continue to look for emerging trends in contact allergy to enable prompt preventative measures to be taken.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.13968","type":"journal-article","created":{"date-parts":[[2021,9,5]],"date-time":"2021-09-05T10:45:55Z","timestamp":1630838755000},"page":"637-642","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Trends in preservative allergy: Benzisothiazolinone emerges from the pack"],"prefix":"10.1111","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7974-914X","authenticated-orcid":false,"given":"Natalie","family":"King","sequence":"first","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital, Leeds Teaching Hospitals Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faheem","family":"Latheef","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital, Leeds Teaching Hospitals Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Wilkinson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Chapel Allerton Hospital, Leeds Teaching Hospitals Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,20]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.01058.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91318-4"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"54","article-title":"Increased rate of patch test reactivity to methyldibromo glutaronitrile","volume":"42","author":"McFadden J","year":"2000","journal-title":"Contact Dermatitis"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01668.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13052"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01774.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13396"},{"key":"e_1_2_9_9_1","unstructured":"European Commission(SCCS) SCoCS. Opinion on methylisothiazolinone (P94) submission II (sensitisation only).http:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_145.pdf2013. Accessed June 2021"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.15875"},{"key":"e_1_2_9_11_1","unstructured":"Commission Regulation (EU) No 1003\/2014 of 18 September 2014 amending Annex V to Regulation (EC) No 1223\/2009 of the European Parliament and of the Council on cosmetic product.http:\/\/data.europa.eu\/eli\/reg\/2014\/1003\/oj. Accessed June 2021."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1997.tb00205.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1976.tb03072.x"},{"key":"e_1_2_9_15_1","unstructured":"Scientific Committee on Consumer Safety 26th June 2012. OPINION ON Benzisothiazolinone COLIPA n\u00b0 P96.https:\/\/ec.europa.eu\/health\/scientific_committees\/consumer_safety\/docs\/sccs_o_099.pdf. Accessed June 2021."},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13430"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.10.063"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000603"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12347"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12741"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.13661"},{"issue":"1","key":"e_1_2_9_22_1","first-page":"37","article-title":"The frequency of contact allergy to four isothiazolinones in a general patch\u2010test population, including a pilot study to determine the optimum patch test concentrations of benzisothiazolinone and octylisothiazolinone","volume":"75","author":"Holden C","year":"2016","journal-title":"Contact Dermatitis"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2012.02135.x"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12546"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0b013e3182a5d8a9"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/DER.0000000000000261"}],"container-title":["Contact Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.13968","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.13968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:01:58Z","timestamp":1692972118000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.13968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,20]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1111\/cod.13968"],"URL":"https:\/\/doi.org\/10.1111\/cod.13968","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,20]]},"assertion":[{"value":"2021-03-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}