{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T13:44:26Z","timestamp":1787233466490,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T00:00:00Z","timestamp":1634774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patch tests (PTs) with two readings have been used for decades to identify the culprit drug in nonimmediate cutaneous adverse drug reactions (NICADRs), followed more recently by late reading of intradermal tests (IDTs). Some teams tend to perform PTs with only one reading before IDTs or even directly perform IDTs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the relevance of a late PT reading on day 4 (D4) in NICADRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively selected patients who had a PT for an NICADR between July 2014 and March 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 328 patients had a PT with available results. Among the 75 positive\u2010PT patients with available data for the two readings, 41 (54.7%) had positive results on D2 and D4 and 34 (45.3%) had negative results on D2 but positive results on D4. No patient had positive results on D2 and negative results on D4.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study shows that a D4 reading enhanced the PT\u2010positive results. A positive PT result allows for reducing the number of IDTs, which are more difficult and costly to perform. Our series suggests that a late PT reading at D4 should be performed for exploring NICADRs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cod.13981","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T04:34:43Z","timestamp":1632976483000},"page":"29-33","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Patch tests in nonimmediate cutaneous adverse drug reactions: The importance of late readings on day 4"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3565-8841","authenticated-orcid":false,"given":"Zo\u00e9","family":"Bhujoo","sequence":"first","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Ingen\u2010Housz\u2010Oro","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital Cr\u00e9teil France"},{"name":"EA7379 EpidermE Univ Paris Est Cr\u00e9teil EpidermE Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Drug Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendeline","family":"Gener","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Drug Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Gaudin","sequence":"additional","affiliation":[{"name":"Dermatology Department APHP, Henri Mondor Hospital Cr\u00e9teil France"},{"name":"Reference Center for Toxic Bullous Diseases and Severe Drug Reactions Cr\u00e9teil France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaux","family":"Fleck","sequence":"additional","affiliation":[{"name":"Dermatology 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