{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:00:00Z","timestamp":1778173200990,"version":"3.51.4"},"reference-count":46,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Several risk factors, among other lifestyle factors, have been suggested for hand eczema (HE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate a possible association between HE and lifestyle factors, including smoking, alcohol consumption, stress, body mass index (BMI), waist circumference, physical activity, diet, and amount of sleep in the Dutch general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the large population\u2010based LifeLines Cohort Study was used. Individuals with HE in the past year were identified by a cross\u2010sectional questionnaire in 2020. At baseline, information on lifestyle factors was collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total 57\u2009046 individuals were included in the present analysis. Smoking \u22658 cigarettes\/day, and smoking \u226515 pack years showed a positive association with HE in the past year. In addition, chronic stress, a BMI\u00a0&gt;30\u2009kg\/m<jats:sup>2<\/jats:sup>, and a waist circumference of &gt;90\u2009cm were positively associated with HE in the past year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The current study indicates that lifestyle factors are associated with HE. Advice regarding lifestyle factors might contribute to enhance overall health, of which HE might possibly benefit in conjunction. Further studies should also focus on the association between lifestyle factors and the severity and prognosis of HE rather than on occurrence alone.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14005","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T09:15:00Z","timestamp":1636708500000},"page":"80-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hand eczema and lifestyle factors in the <scp>D<\/scp>utch general population: Evidence for smoking, chronic stress, and obesity"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-9284","authenticated-orcid":false,"given":"Laura","family":"Loman","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Groningen, University Medical Center Groningen  Groningen The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0766-4382","authenticated-orcid":false,"given":"Marie L. 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