{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T10:22:43Z","timestamp":1775470963322,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T00:00:00Z","timestamp":1638662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Besides being a potential component of (some species of) colophonium, D\u2010limonene is also used as a tackifier in the production of adhesives. Hydroperoxides of limonene are well\u2010known skin sensitizers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To show that D\u2010limonene may be present in colophonium\u2010containing but also colophonium\u2010free (\u201chypoallergenic\u201d) adhesives, and that patients suffering from allergic contact dermatitis (ACD) from both types of adhesives might display positive patch test reactions to limonene hydroperoxides in this regard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Five patients with suspected ACD from adhesives were patch tested to the baseline series (containing limonene hydroperoxides 0.3 and 0.2% pet.), additional series and, if available, to the culprit adhesives. The adhesives labelled as containing colophonium (n\u00a0=\u00a03) or free from it (n\u00a0=\u00a02) were analysed with gas chromatography \u2010 mass spectrometry (GC\u2010MS) for the presence of D\u2010limonene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All five patients sensitised to adhesives had (strong) positive patch test reactions to limonene hydroperoxides. The presence of D\u2010limonene, and\/or related components, could be demonstrated in all three colophonium\u2010containing and, surprisingly, also in two colophonium\u2010free (\u201chypoallergenic\u201d) tapes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>D\u2010limonene may be present in both regular and \u201chypoallergenic\u201d adhesives, with limonene hydroperoxides potentially contributing to ACD from such medical devices. The use of fragrance chemicals in adhesives deserves further research.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cod.14008","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T03:02:27Z","timestamp":1637118147000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Allergic contact dermatitis from (\u201chypoallergenic\u201d) adhesives containing <scp>D<\/scp>\u2010limonene"],"prefix":"10.1111","volume":"86","author":[{"given":"Ella","family":"Dendooven","sequence":"first","affiliation":[{"name":"Department of Dermatology, University Hospital Antwerp (UZA) and Research group Immunology, INFLA\u2010MED Centre of Excellence University of Antwerp  Antwerp Belgium"},{"name":"Research Group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenn","family":"Foubert","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania","family":"Naessens","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Pieters","sequence":"additional","affiliation":[{"name":"Research Group Natural Products &amp; Food \u2013 Research and Analysis (NatuRA), Department of Pharmaceutical Sciences University of Antwerp  Antwerp 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