{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:47:06Z","timestamp":1792496826110,"version":"4.5.0"},"reference-count":75,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contact Dermatitis"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Skin tests, including patch tests (PTs), prick tests, and intradermal tests (IDTs), are useful in identifying the culprits of cutaneous adverse drug reactions (CADRs), and determining safer, alternative drugs. PTs have a low sensitivity but are valuable in investigating maculopapular exanthema (MPE), as well as severe CADR, including toxic epidermal necrolysis (TEN), Stevens\u2010Johnson syndrome (SJS), and in particular, acute generalized exanthematous pustulosis (AGEP), and drug reaction with eosinophilia and systemic symptoms (DRESS). To ensure their specificity, at least 10 control tests should be performed. Prick tests are mainly used in the evaluation of immediate\u2010type hypersensitivity and can be performed with all drugs, except opiates. IDTs can be used to explore immediate and delayed\u2010type hypersensitivity, if an injectable form of the drug exists. Except for SJS\/TEN, IDTs should be performed by injecting 0.02\u2009mL of the drug. We here provide a practical, up\u2010to\u2010date review on the use of these skin tests in the work\u2010up of CADRs. Numerous negative controls for drug PTs, as well as criteria for the immediate and delayed positivity of prick tests and IDT, are included. It should be emphasized that a negative result never excludes the potential responsibility of a drug in a CADR.<\/jats:p>","DOI":"10.1111\/cod.14063","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T08:03:21Z","timestamp":1644048201000},"page":"344-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Skin tests in the work\u2010up of cutaneous adverse drug reactions: A review and update"],"prefix":"10.1111","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8889-1589","authenticated-orcid":false,"given":"Annick","family":"Barbaud","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, Institut Pierre Louis d'Epid\u00e9miologie et de Sant\u00e9 Publique, AP\u2010HP Sorbonne Universit\u00e9, H\u00f4pital Tenon, D\u00e9partement de dermatologie et allergologie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9983-9521","authenticated-orcid":false,"given":"Julie","family":"Castagna","sequence":"additional","affiliation":[{"name":"AP\u2010HP Sorbonne Universit\u00e9, H\u00f4pital Tenon, D\u00e9partement de dermatologie et allergologie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8726-6658","authenticated-orcid":false,"given":"Ang\u00e8le","family":"Soria","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9 INSERM 1135 Cimi\u2010Paris, H\u00f4pital Tenon, Assistance Publique\u2010H\u00f4pitaux de Paris, D\u00e9partement de dermatologie et d'allergologie Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13601\u2010017\u20100144\u20100"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450601.x"},{"issue":"1","key":"e_1_2_14_4_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.0105-4538.2001.00001.x-i8","article-title":"General considerations for skin test procedures in the diagnosis of drug hypersensitivity","volume":"57","author":"Brockow K","year":"2002","journal-title":"Allergy"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12125"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u2010981\u201013\u20101489\u20106_18"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70439-2"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12390"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12720"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12774"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2020.02.033"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.14122"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02728.x"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1710-1492-6-2"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.10.030"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2018.01.005"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01659.x"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.17835"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13380"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12269"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470208.x"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2001.450502.x"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v7.i1.25"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12432"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12842"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12641"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2012.01409.x"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01946.x"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2004.00452.x"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2014.04.006"},{"key":"e_1_2_14_31_1","first-page":"456","volume-title":"Patch Testing. 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Dermatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14063","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cod.14063","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cod.14063","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:35:20Z","timestamp":1700181320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cod.14063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,9]]},"references-count":75,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/cod.14063"],"URL":"https:\/\/doi.org\/10.1111\/cod.14063","archive":["Portico"],"relation":{},"ISSN":["0105-1873","1600-0536"],"issn-type":[{"value":"0105-1873","type":"print"},{"value":"1600-0536","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,9]]},"assertion":[{"value":"2021-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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