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They are pre\u2010haptens, forming hydroperoxides (Lim\u2010OOHs, Lin\u2010OOHs) upon oxidation and inducing frequent positive patch test reactions in patients with dermatitis, and yet they are not routinely tested in Europe. This review evaluates current patch testing with Lim\u2010OOHs and Lin\u2010OOHs by asking whether hydroperoxide patch testing is warranted, examining the difficulties or challenges related to reading and interpreting hydroperoxide patch test results with currently available material, and assessing their relevance. Studies are increasingly pointing to high percentages of positive reactions in patients consecutively patch tested with these oxidized products. An association between a positive clinical history and a strong patch test reaction has been described, but problems with doubtful\/irritant reactions have also been reported. Considering the high frequency of relevant positive reactions, the incorporation of Lim\u2010OOHs 0.3% and Lin\u2010OOHs 1% in the baseline series may be justified. Since exposure, sensitization, and elicitation limits of Lim\u2010OOHs and Lin\u2010OOHs in the products still need to be better determined, an assessment of previous exposure, possible sensitizations, and reactions may help to improve the clinical assessment.<\/jats:p>","DOI":"10.1111\/cod.14064","type":"journal-article","created":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T00:09:21Z","timestamp":1644019761000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Limonene and linalool hydroperoxides review: Pros and cons for routine patch testing"],"prefix":"10.1111","volume":"87","author":[{"given":"Isabel A","family":"Ogueta","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hospital del Mar, IMIM Universitat Aut\u00f2noma  Barcelona Spain"},{"name":"Department of Dermatology, Faculty of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago 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